Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.62 |
| ▸ | HTR1D | P28221 | 1/20 | 0.62 |
| ▸ | HTR2B | P41595 | 1/20 | 0.62 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | PPARA | Q07869 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.42 |
| ▸ | CDK9 | P50750 | 2/20 | 0.42 |
| ▸ | TNKS | O95271 | 1/20 | 0.42 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.42 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8957939 | 0.86 | HTR1A (0.55) | HTR1AHTR1DHTR2BCACNA1GKCNH2 | |
| Hydrochloric Acid SCHEMBL8958128 | 0.86 | HTR1A (0.55) | HTR1AHTR1DHTR2BCACNA1GKCNH2 | |
| SCHEMBL8798591 | 0.85 | HTR1A (0.56) | HTR1AHTR1DHTR2BCACNA1GKCNH2 | |
| SCHEMBL8798584 | 0.85 | HTR1A (0.56) | HTR1AHTR1DHTR2BCACNA1GKCNH2 | |
| SCHEMBL9278928 | 0.81 | PPARG (0.53) | HTR1ACACNA1GKCNH2PPARGPPARA | |
| SCHEMBL8065712 | 0.77 | HTR1A (1.00) | HTR1AHTR1DHTR2BALDH1A1LMNA | |
| SCHEMBL6546383 | 0.77 | HTR1A (1.00) | HTR1AHTR1DHTR2BALDH1A1LMNA | |
| SCHEMBL9001256 | 0.75 | HTR1A (0.68) | HTR1AHTR1DHTR2BCACNA1GKCNH2 | |
| SCHEMBL7937294 | 0.75 | HTR1A (0.52) | HTR1AHTR1DHTR2BALDH1A1LMNA | |
| SCHEMBL8783793 | 0.73 | HTR1A (0.42) | HTR1AHTR1DHTR2BCACNA1GKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0760665-B1 | COMPOSITIONS CONTAINING 5HTIA AND 5HTID ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2001-12-12 | — | — | EP | claimed |
| US-5585374-A | Amide derivatives | JOHN WYETH BROTHER, LIMITED (GB) | 1996-12-17 | — | — | US | claimed |
| EP-0760665-B1 | COMPOSITIONS CONTAINING 5HTIA AND 5HTID ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2001-12-12 | — | — | EP | disclosed |
| EP-0760665-A1 | COMPOSITION CONTAINING 5HT IA? and 5HT ID? ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1997-03-12 | — | — | EP | disclosed |
| US-5585374-A | Amide derivatives | JOHN WYETH BROTHER, LIMITED (GB) | 1996-12-17 | — | — | US | disclosed |
| WO-1995031988-A1 | COMPOSITION CONTAINING 5HTIA and 5HTID ANTAGONISTS | SMITHKLINE BEECHAM P.L.C. (GB) | 1995-11-30 | — | — | WO | disclosed |
| EP-0664801-A1 | AMIDE DERIVATIVES | JOHN WYETH & BROTHER LIMITED (GB) | 1995-08-02 | — | — | EP | disclosed |
| WO-1994003444-A1 | AMIDE DERIVATIVES | JOHN WYETH & BROTHER LIMITED (GB) | 1994-02-17 | — | — | WO | disclosed |