Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 18/20 | 0.60 |
| ▸ | MTNR1B | P49286 | 18/20 | 0.60 |
| ▸ | NQO2 | P16083 | 2/20 | 0.58 |
| ▸ | HTR2C | P28335 | 2/20 | 0.53 |
| ▸ | HTR2B | P41595 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.49 |
| ▸ | MPO | P05164 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9121548 | 0.92 | MTNR1A (0.63) | MTNR1AMTNR1BNQO2HTR2CHTR2B | |
| SCHEMBL8798920 | 0.91 | MTNR1A (0.54) | MTNR1AMTNR1BNQO2HTR2CHTR2B | |
| SCHEMBL9253876 | 0.80 | MAPT (0.51) | HTR2CKDM4EMEN1ALDH1A1CYP1A2 | |
| Hydrochloric Acid SCHEMBL9157724 | 0.79 | MAPT (0.50) | HTR2CKDM4EMEN1ALDH1A1CYP1A2 | |
| SCHEMBL9124933 | 0.79 | MTNR1A (0.65) | MTNR1AMTNR1BALDH1A1 | |
| SCHEMBL9121405 | 0.78 | MTNR1A (0.56) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL9119067 | 0.77 | MTNR1A (0.57) | MTNR1AMTNR1BNQO2ALDH1A1 | |
| SCHEMBL9120386 | 0.77 | MTNR1A (0.67) | MTNR1AMTNR1BALDH1A1 | |
| SCHEMBL9159270 | 0.74 | MTNR1A (0.65) | MTNR1AMTNR1BNQO2HTR2CHTR2B | |
| SCHEMBL9244949 | 0.74 | KDM4E (0.50) | KDM4EALDH1A1CYP3A4CYP2D6HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0506539-B1 | Heterocyclic alkylamides, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1997-05-02 | — | — | EP | disclosed |
| US-5436348-A | Sleep disorders | ADIR ET COMPAGNIE (FR) | 1995-07-25 | — | — | US | disclosed |
| US-5386034-A | Treatment of sleeping, psychological and nervous system disorders; anxiolytic agents, ovulation regulators | ADIR ET COMPAGNIE (FR) | 1995-01-31 | — | — | US | disclosed |
| US-5322843-A | Treating sleep disorders | ADIR ET COMPAGNIE (FR) | 1994-06-21 | — | — | US | disclosed |
| EP-0506539-A1 | Heterocyclic alkylamides, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1992-09-30 | — | — | EP | disclosed |