Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 17/20 | 0.48 |
| ▸ | LTB4R2 | Q9NPC1 | 11/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.39 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8800182 | 0.91 | LTB4R (0.47) | LTB4RLTB4R2CYP2C9PPARD | |
| SCHEMBL9119371 | 0.90 | LTB4R (0.47) | LTB4RLTB4R2CYP2C9CNR1CNR2 | |
| SCHEMBL8463994 | 0.89 | LTB4R (0.54) | LTB4RLTB4R2CYP2C9CNR1CNR2 | |
| SCHEMBL9121586 | 0.88 | LTB4R (0.58) | LTB4RLTB4R2CYP2C9CNR1CNR2 | |
| SCHEMBL9119413 | 0.88 | LTB4R (0.58) | LTB4RLTB4R2CYP2C9CNR1CNR2 | |
| SCHEMBL9121682 | 0.88 | LTB4R (0.58) | LTB4RLTB4R2CYP2C9CNR1CNR2 | |
| SCHEMBL9119183 | 0.88 | LTB4R (0.58) | LTB4RLTB4R2CYP2C9CNR1CNR2 | |
| SCHEMBL9119987 | 0.88 | LTB4R (0.58) | LTB4RLTB4R2CYP2C9CNR1CNR2 | |
| SCHEMBL9122731 | 0.84 | LTB4R (0.48) | LTB4RLTB4R2CYP2C9PPARD | |
| SCHEMBL9122175 | 0.84 | LTB4R (0.52) | LTB4RLTB4R2CYP2C9CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0755381-A1 | SUBSTITUTED PYRIDINE LEUKOTRIENE B 4 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1997-01-29 | — | — | EP | disclosed |
| WO-1995028386-A1 | SUBSTITUTED PYRIDINE LEUKOTRIENE B4 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1995-10-26 | — | — | WO | disclosed |