Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 4/20 | 0.46 |
| ▸ | CES1 | P23141 | 4/20 | 0.46 |
| ▸ | FABP3 | P05413 | 1/20 | 0.44 |
| ▸ | FABP4 | P15090 | 1/20 | 0.44 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 2/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7273539 | 0.84 | MAPT (0.60) | MAPTHSD17B10KDM4EALOX15MAPK1 | |
| SCHEMBL27888985 | 0.84 | MAPT (0.51) | MAPTHSD17B10KDM4EALOX15MAPK1 | |
| SCHEMBL27414108 | 0.83 | MAPT (0.50) | MAPTHSD17B10KDM4EALOX15MAPK1 | |
| SCHEMBL8799869 | 0.82 | FABP3 (0.56) | MAPTHSD17B10ALOX15CES2CES1 | |
| SCHEMBL9765827 | 0.82 | MAPT (0.49) | MAPTHSD17B10KDM4EALOX15MAPK1 | |
| SCHEMBL27870492 | 0.81 | CES2 (0.50) | MAPTHSD17B10KDM4EALOX15MAPK1 | |
| SCHEMBL28418609 | 0.79 | MAPT (0.46) | MAPTHSD17B10KDM4EALOX15MAPK1 | |
| SCHEMBL14052472 | 0.79 | SMN1; SMN2 (0.47) | MAPTHSD17B10KDM4EALOX15MAPK1 | |
| SCHEMBL28184265 | 0.79 | MAPT (0.46) | MAPTHSD17B10KDM4EALOX15MAPK1 | |
| SCHEMBL870485 | 0.78 | NPC1 (0.52) | MAPTKDM4ECES2CES1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772601-A1 | 4,5-SUBSTITUTED IMIDAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |