Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6431490 | 0.90 | KDM4E (0.57) | MAPTKDM4EGAATDP1ALDH1A1 | |
| SCHEMBL31692120 | 0.90 | KDM4E (0.57) | MAPTKDM4EGAATDP1ALDH1A1 | |
| SCHEMBL30884756 | 0.81 | ALDH1A1 (0.45) | MAPTKDM4EGAATDP1ALDH1A1 | |
| SCHEMBL8041232 | 0.81 | ALDH1A1 (0.45) | MAPTKDM4EGAATDP1ALDH1A1 | |
| SCHEMBL31108920 | 0.78 | ALDH1A1 (0.43) | MAPTKDM4EGAATDP1ALDH1A1 | |
| SCHEMBL30197402 | 0.74 | MAPT (0.83) | MAPTKDM4EGAATDP1ALDH1A1 | |
| SCHEMBL159592 | 0.74 | MAPT (0.83) | MAPTKDM4EGAATDP1ALDH1A1 | |
| SCHEMBL21901501 | 0.74 | KDM4E (0.61) | MAPTKDM4EGAATDP1ALDH1A1 | |
| SCHEMBL1535157 | 0.74 | ATM (0.72) | MAPTKDM4ETDP1ALDH1A1LMNA | |
| SCHEMBL11219888 | 0.73 | THRB (0.57) | MAPTKDM4EGAATDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0758333-A1 | INTERMEDIATES IN PHARMACEUTICAL CAMPTOTHECIN PREPARATION | GLAXO WELLCOME INC. (US) | 1997-02-19 | — | — | EP | disclosed |
| WO-1995029917-A2 | INTERMEDIATES IN PHARMACEUTICAL CAMPTOTHECIN PREPARATION | GLAXO WELLCOME INC. (US) | 1995-11-09 | — | — | WO | disclosed |