Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA5A | P35218 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | TDP2 | O95551 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | DRD1 | P21728 | 2/20 | 0.40 |
| ▸ | DRD5 | P21918 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8623559 | 0.87 | GAA (0.50) | METAP1GAACA2CA5ATDP2 | |
| SCHEMBL6111006 | 0.80 | CA12 (0.44) | METAP1GAAEIF2AK2CA12CA9 | |
| SCHEMBL2474488 | 0.78 | METAP1 (0.42) | METAP1ACHEMAOBKDM4EALDH1A1 | |
| SCHEMBL9200636 | 0.75 | TDP2 (0.41) | ACHETDP2MAOBMAPT | |
| SCHEMBL10926837 | 0.75 | ESR2 (0.42) | CA2CA5ATDP2DRD2DRD1 | |
| SCHEMBL31525565 | 0.75 | CA12 (0.54) | METAP1CA2CA5AKDM4ENPC1 | |
| SCHEMBL14495775 | 0.75 | CA12 (0.54) | METAP1CA2CA5AKDM4ENPC1 | |
| SCHEMBL7349547 | 0.73 | MAPT (0.49) | TDP2KDM4ENPC1MAPTHPGD | |
| SCHEMBL14885040 | 0.73 | CA2 (0.45) | METAP1CA2CA5AACHEPDE3B | |
| SCHEMBL28470495 | 0.72 | CA2 (0.45) | METAP1GAACA2CA5AACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0506539-B1 | Heterocyclic alkylamides, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1997-05-02 | — | — | EP | disclosed |
| US-5386034-A | Treatment of sleeping, psychological and nervous system disorders; anxiolytic agents, ovulation regulators | ADIR ET COMPAGNIE (FR) | 1995-01-31 | — | — | US | disclosed |
| US-5326775-A | Treating sleep disorders | ADIR ET COMPAGNIE (FR) | 1994-07-05 | — | — | US | disclosed |
| US-5322843-A | Treating sleep disorders | ADIR ET COMPAGNIE (FR) | 1994-06-21 | — | — | US | disclosed |
| US-5322849-A | Treating sleep disorders | ADIR ET COMPAGNIE (FR) | 1994-06-21 | — | — | US | disclosed |
| US-5300507-A | Treating sleep disorders | ADIR ET COMPAGNIE (FR) | 1994-04-05 | — | — | US | disclosed |
| US-5240919-A | Treating sleep disorders | ADIR ET COMPAGNIE (FR) | 1993-08-31 | — | — | US | disclosed |
| EP-0506539-A1 | Heterocyclic alkylamides, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1992-09-30 | — | — | EP | disclosed |