Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.49 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | GRK6 | P43250 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | QPCT | Q16769 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5726023 | 0.98 | CYP11B1 (0.50) | CYP11B1CYP11B2TLR8MAPK1CNR1 | |
| SCHEMBL23930932 | 0.94 | CYP11B1 (0.51) | CYP11B1CYP11B2TLR8MAPK1CNR1 | |
| SCHEMBL6336700 | 0.85 | CYP11B1 (0.41) | CYP11B1CYP11B2TLR8MAPK1CNR1 | |
| SCHEMBL15202361 | 0.85 | GABRA1 (0.47) | CYP11B1CYP11B2CNR1CYP1A2CYP2C19 | |
| SCHEMBL6701818 | 0.81 | TDP1 (0.39) | TLR8CNR1CYP1A2CYP2C19GAA | |
| SCHEMBL7424605 | 0.81 | CYP11B1 (0.59) | CYP11B1CYP11B2MAPK1CYP1A2CYP2C19 | |
| SCHEMBL31260829 | 0.79 | CYP11B1 (0.46) | CYP11B1CYP11B2MAPK1MEN1KMT2A | |
| SCHEMBL27264726 | 0.78 | CYP11B1 (0.45) | CYP11B1CYP11B2MAPK1TDP1LMNA | |
| SCHEMBL31203889 | 0.77 | CYP11B1 (0.49) | CYP11B1CYP11B2MAPK1CYP1A2CYP2C19 | |
| SCHEMBL18185717 | 0.76 | CYP11B1 (0.55) | CYP11B1CYP11B2MAPK1GRM2HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0482771-B1 | Heterocyclic acids | ZENECA LTD (GB) | 1997-06-18 | — | — | EP | disclosed |
| US-5410064-A | Thromboxane A2 antagonists and inhibitors of thromboxane A2 synthase | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-04-25 | — | — | US | disclosed |
| US-5219874-A | Heterocyclic acids | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-06-15 | — | — | US | disclosed |
| EP-0482771-A2 | Heterocyclic acids | ZENECA LIMITED (GB) | 1992-04-29 | — | — | EP | disclosed |