Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | STAT3 | P40763 | 1/20 | 0.61 |
| ▸ | STAT1 | P42224 | 1/20 | 0.61 |
| ▸ | CES2 | O00748 | 5/20 | 0.51 |
| ▸ | CES1 | P23141 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | ACHE | P22303 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.41 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10376096 | 0.79 | MAPT (0.52) | MAPTNPC1RAB9ASMN1; SMN2TDP1 | |
| SCHEMBL5699982 | 0.76 | TDP1 (0.54) | MAPTNPC1RAB9ASMN1; SMN2TDP1 | |
| SCHEMBL20194021 | 0.76 | MAPT (1.00) | MAPTNPC1RAB9ASMN1; SMN2TDP1 | |
| SCHEMBL27509829 | 0.76 | MAPT (0.36) | MAPTNPC1RAB9ASMN1; SMN2TDP1 | |
| SCHEMBL17446281 | 0.74 | NPC1 (0.61) | MAPTNPC1RAB9ASMN1; SMN2TDP1 | |
| SCHEMBL1405393 | 0.74 | NPC1 (0.61) | MAPTNPC1RAB9ASMN1; SMN2TDP1 | |
| SCHEMBL255052 | 0.74 | NPC1 (0.61) | MAPTNPC1RAB9ASMN1; SMN2TDP1 | |
| SCHEMBL11693056 | 0.74 | NPC1 (0.61) | MAPTNPC1RAB9ASMN1; SMN2TDP1 | |
| SCHEMBL11693067 | 0.74 | NPC1 (0.61) | MAPTNPC1RAB9ASMN1; SMN2TDP1 | |
| SCHEMBL22344758 | 0.72 | MAPT (0.55) | MAPTNPC1RAB9ASMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120130017-A1 | PROCESS AND NEW COMPOUNDS | UNIVERSITY OF LEICESTER (GB) | 2012-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120130017-A1 | PROCESS AND NEW COMPOUNDS | PARG, POLI, NPEPPS | MAPT 3823/4885NPC1 4791/4885RAB9A 4374/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.