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SCHEMBL8799347

SCHEMBL8799347

Cc1cc(NC(=O)C(=O)O)cc(C)c1Oc1ccc(O)c(C(=O)c2ccc(F)cc2)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ THRA P10827 5/20 0.60
▸ THRB P10828 5/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8798549 0.90 THRA (0.64) THRATHRB
SCHEMBL8800248 0.89 THRA (0.60) THRATHRB
SCHEMBL8799539 0.88 THRA (0.68) THRATHRB
SCHEMBL7212348 0.88 THRB (0.61) THRATHRB
SCHEMBL1641091 0.88 THRB (0.61) THRATHRB
SCHEMBL8800464 0.87 THRA (0.48) THRATHRB
SCHEMBL4965106 0.85 THRA (0.50) THRATHRB
SCHEMBL7207345 0.85 THRA (0.50) THRATHRB
SCHEMBL4974242 0.84 THRA (0.62) THRATHRB
SCHEMBL6660195 0.84 THRA (0.64) THRATHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0580550-B1 Oxamic acid derivatives as hypocholesteremic agents CIBA GEIGY AG (CH) 1997-10-22 — — EP disclosed
US-5654468-A ANTILIPID, ANTICHOLESTEROL AGENTS CIBA-GEIGY CORPORATION (US) 1997-08-05 — — US disclosed
US-5569674-A ANTICHOLESTEROL AGENTS CIBA-GEIGY CORPORATION (US) 1996-10-29 — — US disclosed
US-5401772-A Anticholesterol agents with aromatic amines CIBA-GEIGY CORPORATION (US) 1995-03-28 — — US disclosed
EP-0580550-A1 Oxamic acid derivatives as hypocholesteremic agents CIBA-GEIGY AG (CH) 1994-01-26 — — EP disclosed