SCHEMBL8799350

SCHEMBL8799350

CC(=O)OC(=N)C(c1ccc(OCc2cscn2)cc1)C1CCCCC1

nearest known ligand 0.60

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 20/20 0.60
HDAC6 Q9UBN7 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8800021 0.99 ALOX5 (0.58) ALOX5HDAC6
SCHEMBL8967518 0.78 ALOX5 (0.59) ALOX5HDAC6
SCHEMBL8800909 0.76 ALOX5 (0.58) ALOX5HDAC6
SCHEMBL8801122 0.74 ALOX5 (0.60) ALOX5
SCHEMBL8800396 0.72 ALOX5 (0.58) ALOX5HDAC6
SCHEMBL8966886 0.72 ALOX5 (0.53) ALOX5
SCHEMBL8965348 0.72 ALOX5 (0.57) ALOX5HDAC6
SCHEMBL8968723 0.72 ALOX5 (0.54) ALOX5HDAC6
SCHEMBL8799902 0.71 ALOX5 (0.53) ALOX5HDAC6
SCHEMBL8800737 0.71 ALOX5 (0.51) ALOX5HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0772594-A1 IMINOXYCARBOXYLATES AND DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS Abbott Laboratories (US) 1997-05-14 EP claimed
WO-1996002507-A1 IMINOXYCARBOXYLATES AND DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS ABBOTT LABORATORIES (US) 1996-02-01 WO claimed
EP-0772594-A1 IMINOXYCARBOXYLATES AND DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS Abbott Laboratories (US) 1997-05-14 EP disclosed
WO-1996002507-A1 IMINOXYCARBOXYLATES AND DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS ABBOTT LABORATORIES (US) 1996-02-01 WO disclosed