Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | ABCC9 | O60706 | 5/20 | 0.37 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.37 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.37 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 4/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9144927 | 0.83 | BRD4 (0.55) | BRD4POLBABCC9SMN1; SMN2ALDH1A1 | |
| SCHEMBL8799530 | 0.77 | HTR6 (0.37) | POLBHSD11B1ABCC9ABCC8KCNJ11 | |
| SCHEMBL8799345 | 0.77 | HTR6 (0.37) | POLBHSD11B1ABCC9ABCC8KCNJ11 | |
| SCHEMBL8799701 | 0.77 | HTR6 (0.37) | POLBHSD11B1ABCC9ABCC8KCNJ11 | |
| SCHEMBL8799971 | 0.75 | FEN1 (0.36) | BRD4POLBABCC9SMN1; SMN2ALDH1A1 | |
| SCHEMBL2905155 | 0.73 | BRD4 (0.65) | BRD4POLBSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL9149858 | 0.72 | HTR6 (0.40) | BRD4POLBABCC9SMN1; SMN2ALDH1A1 | |
| SCHEMBL2898736 | 0.69 | PKM (0.59) | SMN1; SMN2ALDH1A1PKMMEN1CYP3A4 | |
| SCHEMBL9478042 | 0.67 | MGAT2 (0.39) | BRD4POLBABCC9SMN1; SMN2ALDH1A1 | |
| SCHEMBL8799918 | 0.67 | HTR2C (0.37) | POLBSMN1; SMN2ALDH1A1MAPTHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5700798-A | Methods for using benzoxazines for treating asthma | ZENECA LIMITED (GB) | 1997-12-23 | — | — | US | disclosed |
| EP-0698022-B1 | 1,4-BENZOXAZINE DERIVATIVES AS POTASSIUM CHANNEL OPENERS | ZENECA LTD (GB) | 1997-09-17 | — | — | EP | disclosed |
| EP-0698022-A1 | 1,4-BENZOXAZINE DERIVATIVES AS POTASSIUM CHANNEL OPENERS | ZENECA LTD (GB) | 1996-02-28 | — | — | EP | disclosed |
| US-5486515-A | 2-fluoroalkyl-1,4-benzoxaxines as potassium channel mediators | ZENECA LIMITED (GB) | 1996-01-23 | — | — | US | disclosed |
| WO-1994026739-A1 | 1,4-BENZOXAZINE DERIVATIVES AS POTASSIUM CHANNEL OPENERS | ZENECA LIMITED (GB) | 1994-11-24 | — | — | WO | disclosed |