Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 6/20 | 0.56 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | CYSLTR2 | Q9NS75 | 7/20 | 0.54 |
| ▸ | CYSLTR1 | Q9Y271 | 7/20 | 0.54 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.53 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.52 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.52 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8800566 | 0.90 | ALOX5 (0.56) | ALOX5HDAC6CYSLTR2CYSLTR1GPBAR1 | |
| SCHEMBL8804039 | 0.83 | ALOX5 (0.52) | ALOX5ALOX5APHDAC6CYSLTR2CYSLTR1 | |
| SCHEMBL8804011 | 0.81 | ALOX5 (0.59) | ALOX5ALOX5APHDAC6CYSLTR2CYSLTR1 | |
| SCHEMBL8648673 | 0.78 | ALOX5 (0.67) | ALOX5ALOX5APHDAC6CYSLTR2CYSLTR1 | |
| SCHEMBL7592647 | 0.78 | GPBAR1 (0.54) | ALOX5ALOX5APHDAC6CYSLTR2CYSLTR1 | |
| SCHEMBL10690965 | 0.77 | CYSLTR1 (0.76) | ALOX5ALOX5APCYSLTR2CYSLTR1GPBAR1 | |
| SCHEMBL7603712 | 0.77 | GPBAR1 (0.70) | ALOX5HDAC6CYSLTR2CYSLTR1GPBAR1 | |
| SCHEMBL3519488 | 0.76 | GPBAR1 (0.68) | ALOX5HDAC6CYSLTR2CYSLTR1GPBAR1 | |
| SCHEMBL8814089 | 0.76 | ALOX5 (0.55) | ALOX5HDAC6CYSLTR2CYSLTR1GPBAR1 | |
| SCHEMBL8800164 | 0.75 | ALOX5 (0.81) | ALOX5HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772594-A1 | IMINOXYCARBOXYLATES AND DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | Abbott Laboratories (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996002507-A1 | IMINOXYCARBOXYLATES AND DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | ABBOTT LABORATORIES (US) | 1996-02-01 | — | — | WO | disclosed |