Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | CES2 | O00748 | 2/20 | 0.50 |
| ▸ | CES1 | P23141 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMO | Q99835 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL44517 | 0.86 | LMNA (0.57) | LMNACES2CES1MAPK1ALDH1A1 | |
| SCHEMBL3461505 | 0.84 | LMNA (0.55) | LMNACES2CES1MAPK1ALDH1A1 | |
| SCHEMBL23854664 | 0.81 | LMNA (0.52) | LMNACES2CES1MAPK1ALDH1A1 | |
| SCHEMBL3454583 | 0.81 | TSHR (0.56) | LMNACES2CES1MAPK1ALDH1A1 | |
| SCHEMBL665133 | 0.81 | LMNA (0.55) | LMNACES2CES1MAPK1ALDH1A1 | |
| SCHEMBL8800484 | 0.80 | CES2 (0.51) | LMNACES2CES1MAPK1ALDH1A1 | |
| SCHEMBL31396839 | 0.80 | LMNA (0.59) | LMNACES2CES1MAPK1ALDH1A1 | |
| SCHEMBL28887353 | 0.80 | LMNA (0.50) | LMNACES2CES1MAPK1ALDH1A1 | |
| SCHEMBL27896734 | 0.80 | LMNA (0.50) | LMNACES2CES1MAPK1ALDH1A1 | |
| SCHEMBL11052504 | 0.79 | LMNA (0.53) | LMNACES2CES1MAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772601-A1 | 4,5-SUBSTITUTED IMIDAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |