Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 5/20 | 0.43 |
| ▸ | THRA | P10827 | 4/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | CTSV | O60911 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6660357 | 0.85 | MAPT (0.49) | MEN1MAPTKMT2ACYP19A1CTSV | |
| SCHEMBL5398175 | 0.84 | THRB (0.43) | MEN1MAPTKMT2ATHRBTHRA | |
| SCHEMBL4965062 | 0.82 | THRB (0.48) | MEN1MAPTKMT2ATHRBTHRA | |
| SCHEMBL6736474 | 0.81 | MEN1 (0.46) | MEN1MAPTKMT2ACYP19A1CYP11B1 | |
| SCHEMBL6738412 | 0.81 | MEN1 (0.46) | MEN1MAPTKMT2ACYP19A1CYP11B1 | |
| SCHEMBL6623929 | 0.81 | MAPT (0.37) | MEN1MAPTKMT2ATHRBTHRA | |
| SCHEMBL27559091 | 0.81 | MEN1 (0.45) | MEN1MAPTKMT2ACYP19A1CYP11B1 | |
| SCHEMBL5391540 | 0.78 | POLB (0.39) | MEN1MAPTKMT2ATHRBTHRA | |
| SCHEMBL5401768 | 0.78 | THRB (0.44) | MEN1MAPTKMT2ATHRBTHRA | |
| SCHEMBL27559095 | 0.78 | AR (0.50) | MEN1MAPTKMT2ACYP19A1CTSV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0580550-B1 | Oxamic acid derivatives as hypocholesteremic agents | CIBA GEIGY AG (CH) | 1997-10-22 | — | — | EP | disclosed |
| US-5654468-A | ANTILIPID, ANTICHOLESTEROL AGENTS | CIBA-GEIGY CORPORATION (US) | 1997-08-05 | — | — | US | disclosed |
| US-5569674-A | ANTICHOLESTEROL AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-10-29 | — | — | US | disclosed |
| US-5401772-A | Anticholesterol agents with aromatic amines | CIBA-GEIGY CORPORATION (US) | 1995-03-28 | — | — | US | disclosed |
| EP-0580550-A1 | Oxamic acid derivatives as hypocholesteremic agents | CIBA-GEIGY AG (CH) | 1994-01-26 | — | — | EP | disclosed |