SCHEMBL8799991

SCHEMBL8799991

ClC12CC3CC(C1)C(CCN1CC4CCC(CC4)C1)C(C3)C2

nearest known ligand 0.38

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 1/20 0.38
CYP2D6 P10635 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8799708 0.82 SIGMAR1 (0.37) SIGMAR1
SCHEMBL8799392 0.78 SIGMAR1 (0.37) SIGMAR1
SCHEMBL467301 0.78 SIGMAR1 (0.50) SIGMAR1CYP2D6
SCHEMBL8800045 0.76 SIGMAR1 (0.36) SIGMAR1
SCHEMBL8099046 0.76 SIGMAR1 (0.73) SIGMAR1
SCHEMBL8908789 0.76 SIGMAR1 (0.73) SIGMAR1
SCHEMBL8098407 0.76 SIGMAR1 (0.73) SIGMAR1
SCHEMBL8090287 0.73
SCHEMBL20697759 0.69 GAA (0.32)
SCHEMBL8799238 0.63 GRIN2D (0.45) CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5650406-A ANTISCHIZOPHRENIC AGENT ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) 1997-07-22 US claimed
EP-0757040-A1 ADAMANTANE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF Asahi Kasei Kogyo Kabushiki Kaisha (JP) 1997-02-05 EP claimed
US-5650406-A ANTISCHIZOPHRENIC AGENT ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) 1997-07-22 US disclosed
EP-0757040-A1 ADAMANTANE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF Asahi Kasei Kogyo Kabushiki Kaisha (JP) 1997-02-05 EP disclosed