Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 4/20 | 0.49 |
| ▸ | EGFR | P00533 | 3/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | MALT1 | Q9UDY8 | 3/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 4/20 | 0.45 |
| ▸ | MAPKAPK2 | P49137 | 4/20 | 0.45 |
| ▸ | GALR2 | O43603 | 1/20 | 0.45 |
| ▸ | PAK4 | O96013 | 1/20 | 0.44 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.44 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | BCR | P11274 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8799651 | 0.83 | GALR2 (0.45) | KDREGFRMAPK1MALT1GALR2 | |
| SCHEMBL7854183 | 0.81 | EGFR (0.43) | CHEK1EGFRERBB2MAPK1MALT1 | |
| SCHEMBL8571074 | 0.80 | GRM1 (0.54) | KDREGFRERBB2LCKGRM1 | |
| SCHEMBL4350714 | 0.80 | GRM1 (0.62) | KDREGFRERBB2LCKGRM1 | |
| SCHEMBL7852078 | 0.80 | MALT1 (0.45) | EGFRERBB2MALT1MAPT | |
| SCHEMBL8597285 | 0.80 | EGFR (0.52) | KDREGFRERBB2LCKKCNH2 | |
| SCHEMBL7846724 | 0.79 | KCNH2 (0.66) | KDREGFRERBB2LCKMAPK1 | |
| SCHEMBL7851279 | 0.79 | KCNH2 (0.66) | KDREGFRERBB2LCKMAPK1 | |
| SCHEMBL7844610 | 0.79 | LIMK1 (0.46) | EGFRMAPK1MALT1GALR2ROCK2 | |
| SCHEMBL25385769 | 0.78 | KCNH2 (0.69) | KDREGFRERBB2LCKMALT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-A1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | Dr. Karl Thomae GmbH (DE) | 1997-06-25 | — | — | EP | disclosed |
| WO-1996007657-A1 | PYRIMIDO[5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | DR. KARL THOMAE GMBH (DE) | 1996-03-14 | — | — | WO | disclosed |