Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GALR2 | O43603 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | BCR | P11274 | 1/20 | 0.43 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 5/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 2/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8799995 | 0.83 | CHEK1 (0.51) | GALR2MAPK1ABL1BCRMALT1 | |
| SCHEMBL7853244 | 0.81 | HPGD (0.48) | GALR2MALT1EGFRAURKAAURKB | |
| SCHEMBL7844610 | 0.80 | LIMK1 (0.46) | GALR2MAPK1MALT1SCN9AEGFR | |
| SCHEMBL7853525 | 0.79 | MCHR1 (0.47) | EGFRAURKAAURKBKMO | |
| SCHEMBL7854183 | 0.78 | EGFR (0.43) | GALR2MAPK1ABL1BCRMALT1 | |
| SCHEMBL7852431 | 0.78 | LIMK1 (0.48) | GALR2MAPK1ABL1BCRMALT1 | |
| SCHEMBL7852078 | 0.77 | MALT1 (0.45) | MALT1SCN9AEGFRKMO | |
| SCHEMBL7845264 | 0.77 | EGFR (0.47) | GALR2EGFRKDRAURKAAURKB | |
| SCHEMBL27401069 | 0.76 | KMO (0.52) | GALR2ABL1BCRALDH1A1RAB9A | |
| SCHEMBL7855449 | 0.76 | EGFR (0.46) | GALR2ABL1BCRSCN9AEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-A1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | Dr. Karl Thomae GmbH (DE) | 1997-06-25 | — | — | EP | disclosed |
| WO-1996007657-A1 | PYRIMIDO[5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | DR. KARL THOMAE GMBH (DE) | 1996-03-14 | — | — | WO | disclosed |