Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.72 |
| ▸ | CYSLTR1 | Q9Y271 | 8/20 | 0.66 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.65 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.65 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.63 |
| ▸ | CYSLTR2 | Q9NS75 | 6/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10410351 | 0.92 | ALOX5 (0.65) | ALOX5CYSLTR1FFAR1AKR1B1GPBAR1 | |
| SCHEMBL7808132 | 0.92 | ALOX5 (0.63) | ALOX5CYSLTR1FFAR1AKR1B1 | |
| SCHEMBL1419751 | 0.88 | CYSLTR1 (0.73) | ALOX5CYSLTR1FFAR1AKR1B1GPBAR1 | |
| SCHEMBL8648449 | 0.88 | FFAR1 (0.76) | ALOX5CYSLTR1FFAR1AKR1B1GPBAR1 | |
| SCHEMBL9053379 | 0.87 | ALOX5 (0.72) | ALOX5CYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL17506998 | 0.86 | ALOX5 (0.61) | ALOX5CYSLTR1FFAR1AKR1B1GPBAR1 | |
| SCHEMBL1419872 | 0.86 | FFAR1 (0.77) | ALOX5CYSLTR1FFAR1AKR1B1GPBAR1 | |
| SCHEMBL1419797 | 0.85 | ALOX5 (0.60) | ALOX5CYSLTR1FFAR1AKR1B1GPBAR1 | |
| SCHEMBL8902567 | 0.85 | ALOX5 (0.72) | ALOX5CYSLTR1FFAR1AKR1B1GPBAR1 | |
| SCHEMBL1419915 | 0.85 | ALOX5 (0.72) | ALOX5CYSLTR1FFAR1AKR1B1GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691337-A | TREATING ATHEROSCLEROSIS | BAYER AKTIENGESELLSCHAFT (DE) | 1997-11-25 | — | — | US | disclosed |
| US-5646162-A | ATHEROSCLEROSIS TREATMENT | BAYER AKTIENGESELLSCHAFT (DE) | 1997-07-08 | — | — | US | disclosed |
| EP-0772594-A1 | IMINOXYCARBOXYLATES AND DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | Abbott Laboratories (US) | 1997-05-14 | — | — | EP | disclosed |
| US-5512581-A | ANTIINFLAMMATORY AGENT | ABBOTT LABORATORIES (US) | 1996-04-30 | — | — | US | disclosed |
| WO-1996004246-A1 | PHENYLACETAMIDES HAVING LEUKOTRIENE-ANTAGONISTIC ACTION | LABORATORIOS MENARINI S.A. (ES) | 1996-02-15 | — | — | WO | disclosed |
| WO-1996002507-A1 | IMINOXYCARBOXYLATES AND DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | ABBOTT LABORATORIES (US) | 1996-02-01 | — | — | WO | disclosed |
| EP-0666849-A4 | ARYL AND HETEROARYLMETHOXYPHENYL INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS. | ABBOTT LAB (US) | 1995-12-13 | — | — | EP | disclosed |
| EP-0666849-A1 | ARYL AND HETEROARYLMETHOXYPHENYL INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | ABBOTT LABORATORIES (US) | 1995-08-16 | — | — | EP | disclosed |
| US-5420131-A | Platelet activating factor antagonist or 5-lipoxygenase inhibitors | J. URIACH & CIA, S.A. (ES) | 1995-05-30 | — | — | US | disclosed |
| US-5391747-A | Lipoxygenase inhibitor; used as antiallergic, antiasthmatic and antiinflammatory agent | BAYER AKTIENGESELLSCHAFT (DE) | 1995-02-21 | — | — | US | disclosed |
| EP-0624588-A1 | New quinoline derivatives with pharmacological activity | J. URIACH & CIA. S.A. (ES) | 1994-11-17 | — | — | EP | disclosed |
| US-5358955-A | Antiinflammatory agents | ABBOTT LABORATORIES (US) | 1994-10-25 | — | — | US | disclosed |
| EP-0617032-A1 | Cyanomethylpyridine derivatives as PAF antagonists and 5-lipoxygenase inhibitors | J. URIACH & CIA. S.A. (ES) | 1994-09-28 | — | — | EP | disclosed |
| EP-0610943-A1 | Pyridinium derivatives useful as PAF antagonists | J. URIACH & CIA. S.A. (ES) | 1994-08-17 | — | — | EP | disclosed |
| WO-1994010148-A1 | ARYL AND HETEROARYLMETHOXYPHENYL INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | ABBOTT LABORATORIES (US) | 1994-05-11 | — | — | WO | disclosed |
| US-5192771-A | Lipoxygenase inhibitors as antiinflammatory agents | BAYER AKTIENGESELLSCHAFT (DE) | 1993-03-09 | — | — | US | disclosed |
| US-5091392-A | Enzyme inhibitors | BAYER AKTIENGESELLSCHAFT (DE) | 1992-02-25 | — | — | US | disclosed |
| US-4970215-A | Substituted 4-(quinolin-2-yl-methoxy)phenyl-acetic acid derivatives and anti-allergic use thereof | BAYER AKTIENGESELLSCHAFT (DE) | 1990-11-13 | — | — | US | disclosed |
| US-4929626-A | α-substituted 4-(quinolin-2-yl-methoxy)phenylacetic acids and esters and lipoxygenase inhibition therewith | BAYER AKTIENGESELLSCHAFT (DE) | 1990-05-29 | — | — | US | disclosed |