Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.35 |
| ▸ | TPMT | P51580 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7412458 | 0.80 | NPC1 (0.46) | KDM4EL3MBTL1LMNAALDH1A1SSTR4 | |
| SCHEMBL7410939 | 0.74 | L3MBTL1 (0.46) | KDM4EL3MBTL1LMNAALDH1A1HTT | |
| SCHEMBL7414592 | 0.73 | SSTR4 (0.41) | LMNAALDH1A1SSTR4HTTSMN1; SMN2 | |
| SCHEMBL7408911 | 0.72 | SSTR4 (0.59) | KDM4ELMNAALDH1A1SSTR4HTT | |
| SCHEMBL8802364 | 0.71 | KDM4E (0.41) | KDM4EL3MBTL1ALDH1A1SSTR4TSHR | |
| SCHEMBL8801272 | 0.71 | HDAC3 (0.42) | L3MBTL1SSTR4TSHR | |
| SCHEMBL1257785 | 0.71 | HPGD (0.53) | KDM4EL3MBTL1SMN1; SMN2HPGDTSHR | |
| SCHEMBL7412315 | 0.69 | MEN1 (0.46) | KDM4ELMNAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL18035902 | 0.68 | USP2 (0.50) | KDM4EL3MBTL1LMNAALDH1A1CYP3A4 | |
| SCHEMBL1257783 | 0.67 | KDM4E (0.39) | KDM4EL3MBTL1LMNAALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640080-B1 | SUBSTITUTED INDOLES AS ANGIOTENSIN II ANTAGONISTS | SYNTEX INC (US) | 1997-10-22 | — | — | EP | disclosed |
| EP-0640080-A1 | SUBSTITUTED INDOLES AND AZAINDOLES AS ANGIOTENSIN II ANTAGONISTS. | SYNTEX INC (US) | 1995-03-01 | — | — | EP | disclosed |
| US-5380739-A | Angiotensin II antagonists | SYNTEX (U.S.A.) INC. (US) | 1995-01-10 | — | — | US | disclosed |
| WO-1993023391-A1 | SUBSTITUTED INDOLES AND AZAINDOLES AS ANGIOTENSIN II ANTAGONISTS | SYNTEX (U.S.A.) INC. (US) | 1993-11-25 | — | — | WO | disclosed |