Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 11/20 | 0.68 |
| ▸ | THRB | P10828 | 11/20 | 0.68 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8991623 | 0.94 | THRA (0.60) | THRATHRBMAPT | |
| SCHEMBL6664447 | 0.90 | THRA (0.65) | THRATHRBMAPT | |
| SCHEMBL23983024 | 0.89 | THRA (0.60) | THRATHRB | |
| SCHEMBL6663299 | 0.85 | THRA (0.70) | THRATHRBMAPT | |
| SCHEMBL5417219 | 0.85 | THRB (0.75) | THRATHRB | |
| SCHEMBL8799539 | 0.84 | THRA (0.68) | THRATHRBMAPT | |
| SCHEMBL4964919 | 0.84 | THRB (0.72) | THRATHRB | |
| SCHEMBL6661638 | 0.84 | THRA (0.58) | THRATHRBMAPT | |
| SCHEMBL23863342 | 0.83 | THRA (0.53) | THRATHRBMAPT | |
| SCHEMBL6664392 | 0.83 | THRA (0.60) | THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0580550-B1 | Oxamic acid derivatives as hypocholesteremic agents | CIBA GEIGY AG (CH) | 1997-10-22 | — | — | EP | disclosed |
| US-5654468-A | ANTILIPID, ANTICHOLESTEROL AGENTS | CIBA-GEIGY CORPORATION (US) | 1997-08-05 | — | — | US | disclosed |
| US-5569674-A | ANTICHOLESTEROL AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-10-29 | — | — | US | disclosed |
| US-5401772-A | Anticholesterol agents with aromatic amines | CIBA-GEIGY CORPORATION (US) | 1995-03-28 | — | — | US | disclosed |
| EP-0580550-A1 | Oxamic acid derivatives as hypocholesteremic agents | CIBA-GEIGY AG (CH) | 1994-01-26 | — | — | EP | disclosed |