Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.61 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.61 |
| ▸ | CYSLTR1 | Q9Y271 | 9/20 | 0.55 |
| ▸ | CYSLTR2 | Q9NS75 | 7/20 | 0.55 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.54 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.49 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8965904 | 0.83 | FFAR1 (0.63) | FFAR1AKR1B1CYSLTR1CYSLTR2ALOX5 | |
| SCHEMBL8799828 | 0.79 | CYSLTR2 (0.52) | FFAR1AKR1B1CYSLTR1CYSLTR2ALOX5 | |
| SCHEMBL8800566 | 0.78 | ALOX5 (0.56) | FFAR1AKR1B1CYSLTR1CYSLTR2ALOX5 | |
| SCHEMBL8966509 | 0.77 | ALOX5 (0.55) | FFAR1AKR1B1CYSLTR1CYSLTR2ALOX5 | |
| SCHEMBL9068707 | 0.77 | ALOX5 (0.61) | CYSLTR1CYSLTR2ALOX5 | |
| SCHEMBL8649544 | 0.76 | FFAR1 (0.97) | FFAR1AKR1B1CYSLTR1CYSLTR2ALOX5 | |
| SCHEMBL9460607 | 0.75 | ALOX5 (0.70) | FFAR1AKR1B1CYSLTR1CYSLTR2ALOX5 | |
| SCHEMBL3519488 | 0.75 | GPBAR1 (0.68) | FFAR1AKR1B1CYSLTR1CYSLTR2ALOX5 | |
| SCHEMBL9459821 | 0.75 | ALOX5 (0.72) | FFAR1AKR1B1CYSLTR1CYSLTR2ALOX5 | |
| SCHEMBL9459875 | 0.75 | ALOX5 (0.71) | FFAR1AKR1B1CYSLTR1CYSLTR2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772594-A1 | IMINOXYCARBOXYLATES AND DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | Abbott Laboratories (US) | 1997-05-14 | — | — | EP | claimed |
| WO-1996002507-A1 | IMINOXYCARBOXYLATES AND DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | ABBOTT LABORATORIES (US) | 1996-02-01 | — | — | WO | claimed |
| US-5512581-A | ANTIINFLAMMATORY AGENT | ABBOTT LABORATORIES (US) | 1996-04-30 | — | — | US | disclosed |