Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 7/20 | 0.71 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | PDE9A | O76083 | 1/20 | 0.43 |
| ▸ | PDE1A | P54750 | 1/20 | 0.43 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.43 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9221096 | 0.86 | PNP (0.67) | PNP | |
| SCHEMBL6345393 | 0.83 | PNP (1.00) | PNP | |
| SCHEMBL9220277 | 0.81 | PNP (0.59) | PNP | |
| SCHEMBL9224582 | 0.81 | PNP (0.70) | PNPGFER | |
| SCHEMBL9220598 | 0.77 | PNP (0.69) | PNP | |
| SCHEMBL10650946 | 0.76 | PLA2G7 (0.57) | PNP | |
| SCHEMBL6344896 | 0.71 | PNP (0.75) | PNP | |
| SCHEMBL9166149 | 0.70 | DPYD (0.60) | — | |
| SCHEMBL17139842 | 0.70 | PNP (0.71) | PNP | |
| SCHEMBL6340397 | 0.69 | PNP (0.75) | PNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0460116-B1 | 9-SUBSTITUTED-8-UNSUBSTITUTED-9-DEAZAGUANINES | BIOCRYST PHARM INC (US) | 1997-08-27 | — | — | EP | disclosed |
| US-5565463-A | PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 1996-10-15 | — | — | US | disclosed |
| EP-0460116-A4 | 9-SUBSTITUTED-8-UNSUBSTITUTED-9-DEAZAGUANINES | — | 1992-05-13 | — | — | EP | disclosed |
| EP-0460116-A1 | 9-SUBSTITUTED-8-UNSUBSTITUTED-9-DEAZAGUANINES. | BIOCRYST (US) | 1991-12-11 | — | — | EP | disclosed |
| WO-1990010631-A1 | 9-SUBSTITUTED-8-UNSUBSTITUTED-9-DEAZAGUANINES | BIOCRYST (US) | 1990-09-20 | — | — | WO | disclosed |