Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4717730 | 0.83 | MAPT (0.48) | EGFRMAPTLMNAKMT2ASRC | |
| SCHEMBL290869 | 0.79 | HPGD (0.48) | MAPTLMNAKMT2ASRCALDH1A1 | |
| SCHEMBL4718150 | 0.78 | MAPT (0.43) | EGFRMAPTLMNAKMT2ASRC | |
| SCHEMBL20971097 | 0.77 | ALDH1A1 (0.50) | MAPTLMNAKMT2ASRCALDH1A1 | |
| SCHEMBL8801948 | 0.77 | EGFR (0.47) | EGFRKMT2AALDH1A1HPGDHTT | |
| SCHEMBL5462039 | 0.75 | MAPT (0.49) | EGFRMAPTLMNAKMT2ASRC | |
| SCHEMBL8800625 | 0.75 | EGFR (0.55) | EGFRMAPTLMNAKMT2AALDH1A1 | |
| SCHEMBL15797100 | 0.74 | SRC (0.49) | MAPTLMNAKMT2ASRCALDH1A1 | |
| SCHEMBL22086381 | 0.73 | SRC (0.70) | EGFRMAPTLMNAKMT2ASRC | |
| Hydrochloric Acid SCHEMBL21272879 | 0.72 | PI4KA (0.56) | MAPTLMNAKMT2ASRCALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0482804-B1 | Pyrrolo[2,3-d]pyrimidines with cardiovascular activity, process for their preparation and pharmaceutical compositions containing them | ZENECA LTD (GB) | 1997-01-22 | — | — | EP | disclosed |
| US-5328910-A | Bradycardial agents | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-07-12 | — | — | US | disclosed |
| EP-0482804-A1 | Pyrrolo[2,3-d]pyrimidines with cardiovascular activity, process for their preparation and pharmaceutical compositions containing them | ZENECA LIMITED (GB) | 1992-04-29 | — | — | EP | disclosed |
| EP-0005205-B1 | SUBSTITUTED 5.6-DIMETHYLPYRROLO(2,3-D)PYRIMIDINES, METHODS FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM | Troponwerke GmbH & Co. KG (DE) | 1981-09-09 | — | — | EP | disclosed |
| EP-0005205-A1 | Substituted 5.6-dimethylpyrrolo(2,3-d)pyrimidines, methods for their preparation and medicines containing them | Troponwerke GmbH & Co. KG (DE) | 1979-11-14 | — | — | EP | disclosed |