Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | BCAT2 | O15382 | 5/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27595455 | 0.88 | MAPT (0.45) | MAPTLMNAKMT2ASRCHPGD | |
| SCHEMBL4721077 | 0.86 | PARP1 (0.37) | MAPTLMNAKMT2AHPGDALDH1A1 | |
| SCHEMBL4720475 | 0.83 | BCAT2 (0.42) | MAPTLMNAKMT2AHPGDALDH1A1 | |
| SCHEMBL290869 | 0.81 | HPGD (0.48) | MAPTLMNAKMT2ASRCHPGD | |
| SCHEMBL4718179 | 0.78 | NPC1 (0.41) | MAPTLMNAKMT2AALDH1A1HSD17B10 | |
| SCHEMBL4717730 | 0.78 | MAPT (0.48) | MAPTLMNAKMT2ASRCHPGD | |
| SCHEMBL8801360 | 0.78 | EGFR (0.57) | MAPTLMNAKMT2ASRCHPGD | |
| SCHEMBL4718967 | 0.78 | KDM4E (0.39) | MAPTLMNAKMT2AHPGDALDH1A1 | |
| SCHEMBL4717818 | 0.77 | ALDH1A1 (0.39) | MAPTLMNAKMT2AHPGDALDH1A1 | |
| SCHEMBL27614310 | 0.76 | PARP1 (0.38) | MAPTLMNAKMT2ASRCHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458722-B1 | PYRROLOPYRIMIDINES AS PHOSPHODIESTERASE VII INHIBITORS | MERCK PATENT GMBH (DE) | 2008-10-15 | — | — | EP | claimed |
| EP-1458722-B1 | PYRROLOPYRIMIDINES AS PHOSPHODIESTERASE VII INHIBITORS | MERCK PATENT GMBH (DE) | 2008-10-15 | — | — | EP | disclosed |