Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OXTR | P30559 | 9/20 | 0.45 |
| ▸ | FNTA | P49354 | 1/20 | 0.44 |
| ▸ | FNTB | P49356 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CCKBR | P32239 | 2/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8801083 | 0.95 | OXTR (0.48) | OXTRFNTAFNTBNPSR1MAPT | |
| SCHEMBL8800205 | 0.95 | OXTR (0.51) | OXTRFNTAFNTBNPSR1MAPT | |
| SCHEMBL8800789 | 0.92 | FNTA (0.51) | OXTRFNTAFNTBTP53CCKBR | |
| SCHEMBL8801631 | 0.89 | FNTA (0.55) | OXTRFNTAFNTBNPSR1MAPT | |
| SCHEMBL8801396 | 0.88 | FNTA (0.49) | OXTRFNTAFNTBTP53CCKBR | |
| SCHEMBL8802707 | 0.87 | OXTR (0.56) | OXTRFNTAFNTBTP53CCKBR | |
| SCHEMBL8801881 | 0.87 | FNTA (0.43) | OXTRFNTAFNTBNPSR1MAPT | |
| SCHEMBL8801804 | 0.85 | FNTA (0.54) | OXTRFNTAFNTBSMN1; SMN2TP53 | |
| SCHEMBL8800047 | 0.85 | OXTR (0.43) | OXTRFNTAFNTBNPSR1MAPT | |
| SCHEMBL8669230 | 0.84 | HTR2B (0.45) | FNTAFNTBNPSR1MAPTMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994026723-A2 | ras FARNESYL TRANSFERASE INHIBITORS | GENENTECH, INC. (US) | 1994-11-24 | — | — | WO | claimed |
| EP-0763537-A2 | Non-peptidyl Ras farnesyl transferase inhibitors | GENENTECH, INC. (US) | 1997-03-19 | — | — | EP | disclosed |
| EP-0698015-A1 | PREPARATION OF N-CYANODITHIOIMINO-CARBONATES AND 3-MERCAPTO-5-AMINO-1H-1,2,4-TRIAZOLE | GENENTECH, INC. (US) | 1996-02-28 | — | — | EP | disclosed |
| WO-1994026723-A2 | ras FARNESYL TRANSFERASE INHIBITORS | GENENTECH, INC. (US) | 1994-11-24 | — | — | WO | disclosed |