Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7499654 | 0.91 | SMN1; SMN2 (0.42) | CYP1A2SMN1; SMN2EGLN1GAAKDM4E | |
| SCHEMBL12481306 | 0.81 | CYP1A2 (0.43) | CYP1A2SMN1; SMN2GAAKDM4EALDH1A1 | |
| SCHEMBL24800386 | 0.80 | NPSR1 (0.42) | CYP1A2SMN1; SMN2EGLN1GAAKDM4E | |
| SCHEMBL6360471 | 0.77 | CYP1A2 (0.40) | CYP1A2SMN1; SMN2GAAKDM4EALDH1A1 | |
| SCHEMBL3420317 | 0.76 | AKR1B1 (0.42) | CYP1A2SMN1; SMN2EGLN1GAAKDM4E | |
| SCHEMBL7500533 | 0.75 | SMN1; SMN2 (0.41) | CYP1A2SMN1; SMN2GAAKDM4EALDH1A1 | |
| SCHEMBL10878348 | 0.74 | SMN1; SMN2 (0.40) | CYP1A2SMN1; SMN2GAAKDM4EALDH1A1 | |
| SCHEMBL9506859 | 0.74 | AGBL2 (0.41) | CYP1A2SMN1; SMN2GAAKDM4EALDH1A1 | |
| SCHEMBL7505743 | 0.72 | KDM4E (0.41) | CYP1A2SMN1; SMN2GAAKDM4EALDH1A1 | |
| SCHEMBL27442896 | 0.72 | TSHR (0.48) | EGLN1GAAKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022271562-A1 | HETEROCYCLES AND USES THEREOF | KUMQUAT BIOSCIENCES INC. (US) | 2022-12-29 | — | — | WO | disclosed |
| EP-0482804-B1 | Pyrrolo[2,3-d]pyrimidines with cardiovascular activity, process for their preparation and pharmaceutical compositions containing them | ZENECA LTD (GB) | 1997-01-22 | — | — | EP | disclosed |
| US-5328910-A | Bradycardial agents | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-07-12 | — | — | US | disclosed |
| EP-0482804-A1 | Pyrrolo[2,3-d]pyrimidines with cardiovascular activity, process for their preparation and pharmaceutical compositions containing them | ZENECA LIMITED (GB) | 1992-04-29 | — | — | EP | disclosed |