Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 10/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 4/20 | 0.36 |
| ▸ | CA2 | P00918 | 4/20 | 0.36 |
| ▸ | CA4 | P22748 | 4/20 | 0.36 |
| ▸ | CA7 | P43166 | 4/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8797326 | 0.95 | PTGS2 (0.41) | PTGS2MAPTCA1CA2CA4 | |
| SCHEMBL5594474 | 0.92 | PTGS2 (0.49) | PTGS2PTGS1 | |
| SCHEMBL5595282 | 0.92 | PTGS2 (0.49) | PTGS2PTGS1 | |
| SCHEMBL5594034 | 0.90 | PTGS2 (0.47) | PTGS2CA1CA2CA4CA7 | |
| SCHEMBL5594779 | 0.90 | PTGS2 (0.47) | PTGS2CA1CA2CA4CA7 | |
| SCHEMBL5594142 | 0.87 | PTGS2 (0.52) | PTGS2CA1CA2CA4CA7 | |
| SCHEMBL5594634 | 0.87 | PTGS2 (0.52) | PTGS2CA1CA2CA4CA7 | |
| SCHEMBL8798175 | 0.86 | PTGS2 (0.43) | PTGS2CA1CA2CA4CA7 | |
| SCHEMBL5593908 | 0.85 | PTGS2 (0.52) | PTGS2CA1CA2CA4CA7 | |
| SCHEMBL5593892 | 0.85 | PTGS2 (0.52) | PTGS2CA1CA2CA4CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772600-A1 | 1,2-SUBSTITUTED IMIDAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003388-A1 | 1,2-SUBSTITUTED IMIDAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |