Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 0.43 |
| ▸ | CA1 | P00915 | 3/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | CA4 | P22748 | 3/20 | 0.41 |
| ▸ | CA7 | P43166 | 3/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5594355 | 0.92 | PTGS2 (0.54) | PTGS2CA1CA2CA4CA7 | |
| SCHEMBL5594150 | 0.92 | PTGS2 (0.54) | PTGS2CA1CA2CA4CA7 | |
| SCHEMBL8797326 | 0.91 | PTGS2 (0.41) | PTGS2CA1CA2CA4CA7 | |
| SCHEMBL5594022 | 0.91 | CA2 (0.53) | PTGS2CA1CA2CA4CA7 | |
| SCHEMBL5594490 | 0.91 | CA2 (0.53) | PTGS2CA1CA2CA4CA7 | |
| SCHEMBL8593853 | 0.89 | PTGS2 (0.45) | PTGS2CA1CA2CA4CA7 | |
| SCHEMBL8591718 | 0.89 | PTGS2 (0.45) | PTGS2CA1CA2CA4CA7 | |
| SCHEMBL8801829 | 0.86 | PTGS2 (0.40) | PTGS2CA1CA2CA4CA7 | |
| SCHEMBL8596985 | 0.84 | PTGS2 (0.46) | PTGS2CA1CA2CA4CA7 | |
| SCHEMBL8591715 | 0.83 | PTGS2 (0.40) | PTGS2CA1CA2CA4CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772600-A1 | 1,2-SUBSTITUTED IMIDAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003388-A1 | 1,2-SUBSTITUTED IMIDAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |