Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TOP1 | P11387 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | RARB | P10826 | 1/20 | 0.38 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6220166 | 0.90 | KDM4E (0.48) | KDM4EALDH1A1TOP1POLBHSP90AA1 | |
| SCHEMBL6210378 | 0.87 | KDM4E (0.39) | KDM4EALDH1A1TOP1POLBHSP90AA1 | |
| SCHEMBL8801893 | 0.86 | TOP1 (0.53) | KDM4EALDH1A1TOP1POLBHSP90AA1 | |
| SCHEMBL8803750 | 0.84 | KDM4E (0.38) | KDM4EALDH1A1TOP1POLBHSP90AA1 | |
| SCHEMBL9416404 | 0.83 | EPHA2 (0.38) | KDM4EALDH1A1TOP1POLBHSP90AA1 | |
| SCHEMBL8139307 | 0.82 | ALDH1A1 (0.36) | KDM4EALDH1A1TOP1POLBHSP90AA1 | |
| SCHEMBL8318212 | 0.80 | LMNA (0.42) | KDM4EALDH1A1POLBHSP90AA1RXFP1 | |
| SCHEMBL9182790 | 0.80 | STAT3 (0.53) | KDM4EALDH1A1TOP1POLBHSP90AA1 | |
| SCHEMBL6214215 | 0.79 | HTT (0.44) | KDM4EALDH1A1TOP1POLBHSP90AA1 | |
| SCHEMBL9416468 | 0.79 | MAPK8 (0.43) | KDM4EALDH1A1POLBEPHA2FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0523512-B1 | 8-vinyl- and 8-ethinyl-quinolone carboxylic acids | BAYER AG (DE) | 1997-01-15 | — | — | EP | claimed |
| EP-0523512-A1 | 8-vinyl- and 8-ethinyl-quinolone carboxylic acids | BAYER AG (DE) | 1993-01-20 | — | — | EP | claimed |
| EP-0523512-B1 | 8-vinyl- and 8-ethinyl-quinolone carboxylic acids | BAYER AG (DE) | 1997-01-15 | — | — | EP | disclosed |
| EP-0523512-A1 | 8-vinyl- and 8-ethinyl-quinolone carboxylic acids | BAYER AG (DE) | 1993-01-20 | — | — | EP | disclosed |