Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 2/20 | 0.51 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | KIF11 | P52732 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 2/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP14 | P50281 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7819513 | 0.86 | PGR (0.51) | PGRLMNAMAPK1GAANPC1 | |
| SCHEMBL4717235 | 0.80 | HRH1 (0.56) | HRH1HRH3SMN1; SMN2ROCK2PRKACA | |
| SCHEMBL15030362 | 0.79 | HRH1 (0.59) | HRH1HRH3KDM1AKCNH2ROCK2 | |
| SCHEMBL9760464 | 0.78 | TDP1 (0.58) | PGRLMNAMAPK1HRH3NPC1 | |
| Hydrochloric Acid SCHEMBL4105228 | 0.78 | HRH1 (0.54) | HRH1HRH3SMN1; SMN2ROCK2PRKACA | |
| SCHEMBL31110447 | 0.76 | SLC18A3 (0.47) | LMNAKIF11HPGDSMN1; SMN2KDM1A | |
| SCHEMBL943416 | 0.76 | KCNH2 (0.52) | HRH1LMNASMN1; SMN2KDM1AKCNH2 | |
| SCHEMBL12070796 | 0.75 | HRH1 (0.54) | HRH1HRH3KDM1AKCNH2ROCK2 | |
| SCHEMBL8799792 | 0.75 | HRH1 (0.54) | HRH1HRH3ALDH1A1KCNH2ROCK2 | |
| Hydrochloric Acid SCHEMBL31110480 | 0.75 | HTR2C (0.46) | LMNAKIF11HPGDSMN1; SMN2KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0635505-B1 | 4-Aryloxy- and 4-arylthiopiperidine derivatives | MERCK PATENT GMBH (DE) | 1997-10-15 | — | — | EP | disclosed |
| US-5561145-A | 4-aryloxy- and 4-arylthiopiperidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESHRANKTER HAFTUNG (DE) | 1996-10-01 | — | — | US | disclosed |
| EP-0635505-A1 | 4-Aryloxy- and 4-arylthiopiperidine derivatives | MERCK PATENT GmbH (DE) | 1995-01-25 | — | — | EP | disclosed |