Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.49 |
| ▸ | HTR3A | P46098 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | AR | P10275 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29813099 | 0.84 | SCN9A (0.48) | TDP1ADRB1NPC1RAB9ASLC6A2 | |
| SCHEMBL5564172 | 0.81 | TDP1 (0.63) | TDP1SLC6A2SLC6A4KCNH2SLC6A3 | |
| SCHEMBL8801971 | 0.78 | HRH1 (0.51) | NPC1RAB9AKCNH2HPGDSMN1; SMN2 | |
| SCHEMBL12659968 | 0.78 | TDP1 (0.58) | TDP1SLC6A2SLC6A4KCNH2SLC6A3 | |
| Hydrochloric Acid SCHEMBL9444476 | 0.77 | KDM4E (0.51) | HPGDSMN1; SMN2LMNAKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL384404 | 0.77 | TDP1 (0.61) | TDP1SLC6A2SLC6A4KCNH2SLC6A3 | |
| SCHEMBL26966823 | 0.76 | NPC1 (0.48) | ADRB1NPC1RAB9AKCNH2HPGD | |
| SCHEMBL1474972 | 0.76 | MRGPRX1 (0.52) | TDP1SLC6A2SLC6A4KCNH2HTR3A | |
| SCHEMBL82372 | 0.76 | TDP1 (0.73) | TDP1SLC6A2SLC6A4KCNH2SLC6A3 | |
| SCHEMBL8781070 | 0.75 | MMP2 (0.61) | TDP1ADRB1NPC1RAB9AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5057528-A | AMINO-PYRIDINE COMPOUNDS USEFUL AS ANTI-ARRHYTHMIC AGENTS | PFIZER INC. (US) | 1991-10-15 | — | — | US | disclosed |
| EP-0359389-A1 | Antiarrhythmic agents | Pfizer Limited (GB) | 1990-03-21 | — | — | EP | disclosed |