Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CASP6 | P55212 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14047501 | 0.90 | ALDH1A1 (0.60) | TSHRALDH1A1HPGDSMN1; SMN2POLB | |
| SCHEMBL14047437 | 0.78 | LMNA (0.56) | ALDH1A1HPGDSMN1; SMN2MEN1KMT2A | |
| SCHEMBL13522333 | 0.76 | NPC1 (0.65) | ALDH1A1SMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL12162761 | 0.74 | NPC1 (0.48) | TSHRALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL6091201 | 0.71 | ALDH1A1 (0.59) | TSHRALDH1A1HPGDSMN1; SMN2MEN1 | |
| SCHEMBL14047502 | 0.70 | ALDH1A1 (0.56) | TSHRALDH1A1HPGDSMN1; SMN2POLB | |
| SCHEMBL6086619 | 0.70 | ALDH1A1 (0.67) | TSHRALDH1A1HPGDSMN1; SMN2MEN1 | |
| SCHEMBL348371 | 0.69 | TSHR (0.60) | TSHRALDH1A1HPGDPOLBMEN1 | |
| SCHEMBL2208204 | 0.68 | ALDH1A1 (0.72) | TSHRALDH1A1HPGDSMN1; SMN2MEN1 | |
| SCHEMBL6087860 | 0.68 | SMN1; SMN2 (0.66) | TSHRALDH1A1HPGDSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2433634-A2 | Compounds, compositions and methods of inhibiting a-synuclein toxicity | The Whitehead Institute for Biomedical Research (US) | 2012-03-28 | — | — | EP | disclosed |