Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 9/20 | 0.61 |
| ▸ | PDGFRA | P16234 | 9/20 | 0.61 |
| ▸ | FYN | P06241 | 3/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | TDO2 | P48775 | 2/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | GAK | O14976 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8801747 | 0.85 | PDGFRB (0.63) | PDGFRBPDGFRAKITIDO1TDO2 | |
| SCHEMBL8801571 | 0.79 | PDGFRB (0.58) | PDGFRBPDGFRAFYNKITIDO1 | |
| SCHEMBL8502238 | 0.76 | PDGFRB (1.00) | PDGFRBPDGFRA | |
| SCHEMBL8801931 | 0.76 | PDGFRB (0.61) | PDGFRBPDGFRAGAK | |
| SCHEMBL12074128 | 0.76 | BRD4 (0.48) | PDGFRBPDGFRAFYNKITGAK | |
| SCHEMBL15577455 | 0.75 | PDGFRB (0.64) | PDGFRBPDGFRAFYNKIT | |
| SCHEMBL12074706 | 0.74 | FYN (0.47) | FYNKITIDO1TDO2GAK | |
| SCHEMBL17946010 | 0.74 | PDGFRB (0.62) | PDGFRBPDGFRAFYNPDE4BKIT | |
| SCHEMBL28237868 | 0.73 | FYN (0.66) | PDGFRBPDGFRAFYNKITGAK | |
| SCHEMBL28421266 | 0.73 | BRD4 (0.61) | FYNKITGAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0584222-B1 | BIS MONO-AND BICYCLIC ARYL AND HETEROARYL COMPOUNDS WHICH INHIBIT EGF AND/OR PDGF RECEPTOR TYROSINE KINASE | RHONE POULENC RORER INT (US) | 1997-10-08 | — | — | EP | claimed |