Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 11/20 | 0.61 |
| ▸ | PDGFRA | P16234 | 10/20 | 0.61 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.51 |
| ▸ | GAK | O14976 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8801571 | 0.79 | PDGFRB (0.58) | PDGFRBPDGFRAGAKNPC1 | |
| SCHEMBL12074128 | 0.78 | BRD4 (0.48) | PDGFRBPDGFRAGAKBRD4 | |
| SCHEMBL8801747 | 0.77 | PDGFRB (0.63) | PDGFRBPDGFRAGAKNPC1 | |
| SCHEMBL28421266 | 0.76 | BRD4 (0.61) | GAKBRD4 | |
| SCHEMBL8172666 | 0.76 | PDGFRB (1.00) | PDGFRBPDGFRA | |
| SCHEMBL8802604 | 0.76 | PDGFRB (0.61) | PDGFRBPDGFRAGAK | |
| SCHEMBL12074863 | 0.75 | GAK (0.48) | PDGFRBPDGFRAGAKBRD4 | |
| SCHEMBL8801463 | 0.74 | PDGFRB (0.54) | PDGFRBPDGFRACYP2A6GAK | |
| SCHEMBL29234155 | 0.72 | ERN1 (0.58) | PDGFRBPDGFRACYP2A6NPC1 | |
| SCHEMBL8500071 | 0.72 | PDGFRB (1.00) | PDGFRBPDGFRACYP2A6NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0584222-B1 | BIS MONO-AND BICYCLIC ARYL AND HETEROARYL COMPOUNDS WHICH INHIBIT EGF AND/OR PDGF RECEPTOR TYROSINE KINASE | RHONE POULENC RORER INT (US) | 1997-10-08 | — | — | EP | claimed |