Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | GFER | P55789 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.50 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8802388 | 0.99 | TSHR (0.65) | TSHRMAPTNPSR1ALDH1A1KDM4E | |
| SCHEMBL1708867 | 0.81 | TSHR (1.00) | TSHRMAPTALDH1A1KDM4ELMNA | |
| SCHEMBL4716406 | 0.81 | TSHR (0.78) | TSHRMAPTNPSR1ALDH1A1KDM4E | |
| SCHEMBL3921818 | 0.79 | TSHR (0.97) | TSHRMAPTALDH1A1KDM4ELMNA | |
| Hydrochloric Acid SCHEMBL9436788 | 0.79 | MAPT (0.58) | MAPTALDH1A1KDM4ELMNAKMT2A | |
| SCHEMBL8803257 | 0.78 | TSHR (0.64) | TSHRMAPTALDH1A1KDM4ELMNA | |
| Hydrochloric Acid SCHEMBL9364154 | 0.77 | LMNA (0.60) | LMNA | |
| SCHEMBL8802382 | 0.76 | TSHR (0.62) | TSHRMAPTALDH1A1KDM4ELMNA | |
| Hydrochloric Acid SCHEMBL9436702 | 0.76 | TDP1 (0.64) | TSHRMAPTALDH1A1LMNAKMT2A | |
| SCHEMBL493045 | 0.74 | POLB (0.72) | TSHRMAPTALDH1A1KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0556673-B1 | Ortho-substituted benzoylguanidines, process for their preparation, their use as medicament or diagnostic agent, as well as medicaments containing them | HOECHST AG (DE) | 1997-09-17 | — | — | EP | disclosed |
| EP-0556673-A1 | Ortho-substituted benzoylguanidines for the treatment and prophylaxis of heart-rhythm disorders and ischaemically induced damage, as well as inhibition of cell proliferation | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-08-25 | — | — | EP | disclosed |