Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.72 |
| ▸ | RAB9A | P51151 | 1/20 | 0.69 |
| ▸ | USP2 | O75604 | 1/20 | 0.68 |
| ▸ | TSHR | P16473 | 5/20 | 0.67 |
| ▸ | MCOLN3 | Q8TDD5 | 3/20 | 0.67 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.67 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.67 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL494192 | 0.98 | KDM4E (0.74) | POLBKDM4ERAB9AUSP2TSHR | |
| SCHEMBL16733049 | 0.84 | HSD17B10 (0.61) | POLBKDM4EUSP2TSHRMCOLN3 | |
| SCHEMBL15010831 | 0.84 | ALDH1A1 (0.73) | POLBKDM4ERAB9AUSP2TSHR | |
| SCHEMBL13489662 | 0.82 | MAPT (0.70) | POLBKDM4ERAB9AUSP2L3MBTL1 | |
| SCHEMBL8049609 | 0.82 | RAB9A (0.85) | POLBKDM4ERAB9AUSP2TSHR | |
| SCHEMBL20526493 | 0.82 | KDM4E (0.63) | POLBKDM4ERAB9AUSP2TSHR | |
| SCHEMBL4716108 | 0.82 | NPBWR1 (0.67) | POLBKDM4EUSP2TSHRMCOLN3 | |
| SCHEMBL11009495 | 0.82 | KDM4E (0.77) | POLBKDM4ERAB9AUSP2TSHR | |
| SCHEMBL5249795 | 0.81 | L3MBTL1 (0.86) | POLBUSP2L3MBTL1ALDH1A1MEN1 | |
| SCHEMBL5251337 | 0.81 | L3MBTL1 (0.86) | POLBUSP2L3MBTL1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2760839-A1 | PYRIDINEDIONE CARBOXAMIDE INHIBITORS OF ENDOTHELIAL LIPASE | Bristol-Myers Squibb Company (US) | 2014-08-06 | — | — | EP | disclosed |
| WO-2013049104-A1 | PYRIDINEDIONE CARBOXAMIDE INHIBITORS OF ENDOTHELIAL LIPASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-04-04 | — | — | WO | disclosed |
| US-8106055-B2 | Substituted amide compounds | GRUENENTHAL GMBH (DE) | 2012-01-31 | — | — | US | disclosed |
| EP-1981848-A2 | 11-BETA HSD1 INHIBITORS | Wyeth (US) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007092435-A2 | 11-BETA HSD1 INHIBITORS | WYETH (US) | 2007-08-16 | — | — | WO | disclosed |