Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 3/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | USP1 | O94782 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8804958 | 0.88 | AGTR1 (0.52) | AGTR1TBXA2RAGTR2PDE3A | |
| SCHEMBL683809 | 0.87 | AGTR1 (0.51) | AGTR1TBXA2RAGTR2PDE3A | |
| SCHEMBL683808 | 0.85 | AGTR1 (0.45) | AGTR1TBXA2RAGTR2PDE3AUSP1 | |
| SCHEMBL684172 | 0.82 | AGTR1 (0.44) | AGTR1TBXA2RAGTR2PDE3A | |
| SCHEMBL683804 | 0.75 | AGTR1 (0.66) | AGTR1TBXA2RAGTR2PDE3A | |
| SCHEMBL683880 | 0.71 | AGTR1 (0.56) | AGTR1TBXA2RAGTR2PDE3A | |
| SCHEMBL683800 | 0.70 | AGTR1 (0.55) | AGTR1TBXA2RAGTR2PDE3A | |
| SCHEMBL682681 | 0.68 | AGTR1 (0.46) | AGTR1TBXA2RAGTR2PDE3A | |
| SCHEMBL12894934 | 0.67 | AGTR1 (0.40) | AGTR1TBXA2RAGTR2PDE3A | |
| SCHEMBL8804378 | 0.65 | AGTR1 (0.51) | AGTR1TBXA2RAGTR2PDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0539086-B1 | Condensed pyrimidine derivatives and their use as angiotensine II antagonists | AMERICAN HOME PROD (US) | 1997-12-29 | — | — | EP | disclosed |
| US-5256654-A | Substituted pyrrolopyrimidines, azepinopyrimidines and pyridopyrimidines useful as angiotensin II antagonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-10-26 | — | — | US | disclosed |
| EP-0539086-A2 | Condensed pyrimidine derivatives and their use as angiotensine II antagonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-04-28 | — | — | EP | disclosed |
| US-5149699-A | Substituted pyridopyrimidines useful as antgiotensin II antagonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-09-22 | — | — | US | disclosed |