Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 2/20 | 0.51 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.51 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | PRKAG1 | P54619 | 3/20 | 0.43 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.43 |
| ▸ | PRKAB1 | Q9Y478 | 3/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL683804 | 0.87 | AGTR1 (0.66) | AGTR1TBXA2RAGTR2PDE3AACHE | |
| SCHEMBL8803987 | 0.81 | AGTR1 (0.56) | AGTR1TBXA2RAGTR2PDE3A | |
| SCHEMBL683809 | 0.77 | AGTR1 (0.51) | AGTR1TBXA2RAGTR2PDE3AACHE | |
| SCHEMBL8804958 | 0.74 | AGTR1 (0.52) | AGTR1TBXA2RAGTR2PDE3A | |
| SCHEMBL7428240 | 0.72 | AGTR1 (0.54) | AGTR1TBXA2RAGTR2PDE3A | |
| SCHEMBL8804016 | 0.71 | PPARG (0.48) | AGTR1ACHEPRKAG1PRKAA1PRKAB1 | |
| SCHEMBL9030149 | 0.71 | PRKAG1 (0.53) | AGTR1ACHEPRKAG1PRKAA1PRKAB1 | |
| SCHEMBL683885 | 0.70 | AGTR1 (0.65) | AGTR1TBXA2RAGTR2PDE3A | |
| SCHEMBL684179 | 0.69 | AGTR1 (0.43) | AGTR1TBXA2RAGTR2PDE3A | |
| SCHEMBL13714544 | 0.69 | AGTR1 (0.68) | AGTR1TBXA2RAGTR2PDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0539086-B1 | Condensed pyrimidine derivatives and their use as angiotensine II antagonists | AMERICAN HOME PROD (US) | 1997-12-29 | — | — | EP | disclosed |
| US-5498776-A | Substituted pyrrolopyrimidines and pyridopyrimidines useful as angiotensin II antagonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-03-12 | — | — | US | disclosed |
| US-5256654-A | Substituted pyrrolopyrimidines, azepinopyrimidines and pyridopyrimidines useful as angiotensin II antagonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-10-26 | — | — | US | disclosed |
| EP-0539086-A2 | Condensed pyrimidine derivatives and their use as angiotensine II antagonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-04-28 | — | — | EP | disclosed |
| US-5149699-A | Substituted pyridopyrimidines useful as antgiotensin II antagonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-09-22 | — | — | US | disclosed |