Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 4/20 | 0.54 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.54 |
| ▸ | XIAP | P98170 | 9/20 | 0.51 |
| ▸ | NPY1R | P25929 | 5/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9274648 | 1.00 | GHSR (0.54) | GHSRAGTR1XIAPNPY1R | |
| SCHEMBL9180913 | 0.93 | GHSR (0.52) | GHSRAGTR1XIAPNPY1R | |
| SCHEMBL9180918 | 0.93 | GHSR (0.52) | GHSRAGTR1XIAPNPY1R | |
| SCHEMBL9088672 | 0.91 | GHSR (0.54) | GHSRAGTR1XIAPNPY1R | |
| SCHEMBL9261142 | 0.89 | GHSR (0.48) | GHSRAGTR1XIAPNPY1R | |
| SCHEMBL8331071 | 0.89 | GHSR (0.52) | GHSRAGTR1XIAPNPY1R | |
| SCHEMBL9260738 | 0.88 | GHSR (0.47) | GHSRAGTR1XIAPNPY1R | |
| SCHEMBL9024956 | 0.88 | GHSR (0.55) | GHSRAGTR1XIAPNPY1R | |
| SCHEMBL9090948 | 0.88 | GHSR (0.56) | GHSRAGTR1XIAPNPY1R | |
| SCHEMBL7791573 | 0.88 | GHSR (0.66) | GHSRAGTR1XIAPNPY1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0726901-A4 | BENZO-FUSED MACROCYCLES PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO INC (US) | 1997-01-22 | — | — | EP | disclosed |
| EP-0726901-A1 | BENZO-FUSED MACROCYCLES PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO. INC. (US) | 1996-08-21 | — | — | EP | disclosed |
| US-5438136-A | Benzo-fused macrocycles promote release of growth hormone | MERCK & CO., INC. (US) | 1995-08-01 | — | — | US | disclosed |
| WO-1995012598-A1 | BENZO-FUSED MACROCYCLES PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1995-05-11 | — | — | WO | disclosed |