Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 4/20 | 0.47 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.47 |
| ▸ | XIAP | P98170 | 8/20 | 0.44 |
| ▸ | ACE | P12821 | 2/20 | 0.40 |
| ▸ | NPY1R | P25929 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9261142 | 0.98 | GHSR (0.48) | GHSRAGTR1XIAPACENPY1R | |
| SCHEMBL8804065 | 0.88 | GHSR (0.54) | GHSRAGTR1XIAPNPY1R | |
| SCHEMBL9274648 | 0.88 | GHSR (0.54) | GHSRAGTR1XIAPNPY1R | |
| SCHEMBL9177730 | 0.87 | XIAP (0.41) | GHSRAGTR1XIAPACE | |
| SCHEMBL9180918 | 0.86 | GHSR (0.52) | GHSRAGTR1XIAPNPY1R | |
| SCHEMBL9180913 | 0.86 | GHSR (0.52) | GHSRAGTR1XIAPNPY1R | |
| SCHEMBL9179425 | 0.84 | GHSR (0.51) | GHSRAGTR1XIAPNPY1R | |
| SCHEMBL9179437 | 0.84 | GHSR (0.51) | GHSRAGTR1XIAPNPY1R | |
| SCHEMBL9088672 | 0.83 | GHSR (0.54) | GHSRAGTR1XIAPNPY1R | |
| SCHEMBL9025316 | 0.82 | GHSR (0.54) | GHSRAGTR1XIAPACENPY1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5438136-A | Benzo-fused macrocycles promote release of growth hormone | MERCK & CO., INC. (US) | 1995-08-01 | — | — | US | disclosed |
| WO-1995012598-A1 | BENZO-FUSED MACROCYCLES PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1995-05-11 | — | — | WO | disclosed |