Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | MIF | P14174 | 1/20 | 0.43 |
| ▸ | FDFT1 | P37268 | 2/20 | 0.43 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8803722 | 0.88 | TAAR1 (0.55) | TAAR1HDAC1HDAC8MAOBMIF | |
| SCHEMBL29819537 | 0.83 | HDAC1 (0.43) | HDAC1MAOB | |
| SCHEMBL8956085 | 0.81 | KCNH2 (0.53) | DAO | |
| SCHEMBL11516270 | 0.81 | TAAR1 (0.52) | TAAR1HDAC1HDAC8MAOBMIF | |
| SCHEMBL3244845 | 0.81 | TAAR1 (0.52) | TAAR1HDAC1HDAC8MAOBMIF | |
| SCHEMBL7861902 | 0.79 | TAAR1 (0.46) | TAAR1HDAC1HDAC8MAOBMIF | |
| SCHEMBL8063276 | 0.78 | TAAR1 (0.46) | TAAR1HDAC1MAOBIDO1 | |
| SCHEMBL1119524 | 0.78 | TAAR1 (0.57) | TAAR1HDAC1HDAC8MAOBMIF | |
| SCHEMBL11328438 | 0.77 | TDP1 (0.48) | HDAC1MAOB | |
| SCHEMBL29217245 | 0.77 | GPR84 (0.43) | MAOBDAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0492474-B1 | 1,3-Dioxolane derivatives as cholesterol-lowering agents | SYNTEX INC (US) | 1997-03-05 | — | — | EP | disclosed |
| US-5158949-A | 1,3-DIOXOLANE DERIVATIVES AS CHOLESTEROL-LOWERING AGENTS | SYNTEX (U.S.A.) INC. (US) | 1992-10-27 | — | — | US | disclosed |
| EP-0492474-A1 | 1,3-Dioxolane derivatives as cholesterol-lowering agents | SYNTEX (U.S.A.) INC. (US) | 1992-07-01 | — | — | EP | disclosed |