Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8239013 | 0.76 | SLC6A3 (0.64) | SLC6A3SLC6A4LMNA | |
| SCHEMBL18769444 | 0.74 | SLC6A3 (0.57) | SLC6A3SLC6A4LMNACYP3A4ALDH1A1 | |
| SCHEMBL558007 | 0.74 | SLC6A3 (0.97) | SLC6A3SLC6A4LMNA | |
| SCHEMBL13073555 | 0.73 | SLC6A3 (0.54) | SLC6A3SLC6A4CYP3A4ALDH1A1HSD17B10 | |
| SCHEMBL3604519 | 0.73 | SLC6A3 (0.56) | SLC6A3SLC6A4LMNACYP3A4ALDH1A1 | |
| Hydrochloric Acid SCHEMBL18742757 | 0.73 | SLC6A3 (0.55) | SLC6A3SLC6A4LMNACYP3A4ALDH1A1 | |
| SCHEMBL8285885 | 0.73 | SLC6A3 (0.62) | SLC6A3SLC6A4LMNAHDAC1ALDH1A1 | |
| SCHEMBL21937622 | 0.73 | SLC6A3 (0.55) | SLC6A3SLC6A4LMNAHDAC1ALDH1A1 | |
| SCHEMBL3519183 | 0.73 | SLC6A3 (0.55) | SLC6A3SLC6A4LMNACYP3A4HDAC1 | |
| SCHEMBL1684359 | 0.73 | HDAC1 (0.55) | SLC6A3SLC6A4HDAC1ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0625507-B1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO (JP) | 1997-07-23 | — | — | EP | disclosed |
| US-5621010-A | ANTIHYPERCHOLESTEROLEMIA AND ANTIATHEROSCLEROSIS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1997-04-15 | — | — | US | disclosed |
| EP-0625507-A2 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1994-11-23 | — | — | EP | disclosed |