Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 18/20 | 0.97 |
| ▸ | LMNA | P02545 | 1/20 | 0.79 |
| ▸ | SLC6A4 | P31645 | 15/20 | 0.71 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.53 |
| ▸ | DPP4 | P27487 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3517809 | 0.98 | SLC6A3 (1.00) | SLC6A3LMNASLC6A4SLC6A2 | |
| SCHEMBL13253942 | 0.83 | SLC6A4 (1.00) | SLC6A3LMNASLC6A4SLC6A2 | |
| SCHEMBL13253939 | 0.83 | SLC6A4 (1.00) | SLC6A3LMNASLC6A4SLC6A2 | |
| SCHEMBL3525151 | 0.83 | SLC6A3 (0.70) | SLC6A3LMNASLC6A4SLC6A2 | |
| SCHEMBL3523743 | 0.83 | SLC6A4 (1.00) | SLC6A3LMNASLC6A4SLC6A2 | |
| SCHEMBL8176455 | 0.81 | SLC6A3 (0.66) | SLC6A3LMNASLC6A4 | |
| SCHEMBL8804864 | 0.80 | SLC6A3 (0.97) | SLC6A3LMNASLC6A4SLC6A2 | |
| SCHEMBL3516980 | 0.78 | SLC6A3 (1.00) | SLC6A3LMNASLC6A4SLC6A2 | |
| SCHEMBL3519338 | 0.78 | SLC6A3 (1.00) | SLC6A3LMNASLC6A4SLC6A2 | |
| SCHEMBL8317366 | 0.76 | SLC6A3 (0.60) | SLC6A3LMNASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130012536-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-01-10 | — | — | US | disclosed |
| US-20120035179-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED | 2012-02-09 | — | — | US | disclosed |
| US-20100125090-A1 | Modulators of ATP-Binding Cassette Transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-05-20 | — | — | US | disclosed |
| US-7598412-B2 | Modulators of ATP-binding cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-10-06 | — | — | US | disclosed |
| EP-1680411-A2 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS CONTAINING CYCLOALKYL OR PYRANYL GROUPS | Vertex Pharmaceuticals Incorporated (US) | 2006-07-19 | — | — | EP | disclosed |
| US-20050148648-A1 | Modulators of ATP-binding cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED | 2005-07-07 | — | — | US | disclosed |
| WO-2005035514-A2 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS CONTAINING CYCLOALKYL OR PYRANYL GROUPS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2005-04-21 | — | — | WO | disclosed |
| EP-0625507-B1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO (JP) | 1997-07-23 | — | — | EP | disclosed |
| US-5621010-A | ANTIHYPERCHOLESTEROLEMIA AND ANTIATHEROSCLEROSIS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1997-04-15 | — | — | US | disclosed |
| EP-0625507-A2 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1994-11-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050148648-A1 | Modulators of ATP-binding cassette transporters | ABCB11, ABCB1, ABCC5 | SLC6A3 163/4885LMNA 1873/4885SLC6A4 177/4885 |
| US-20130012536-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | ABCB11, ABCB1, ABCC5 | SLC6A3 163/4885LMNA 1873/4885SLC6A4 177/4885 |
| US-20100125090-A1 | Modulators of ATP-Binding Cassette Transporters | ABCB11, ABCB1, ABCC5 | SLC6A3 163/4885LMNA 1873/4885SLC6A4 177/4885 |
| US-20120035179-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | ABCB11, ABCB1, ABCC5 | SLC6A3 163/4885LMNA 1873/4885SLC6A4 177/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.