Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 19/20 | 0.85 |
| ▸ | PPARA | Q07869 | 17/20 | 0.85 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8804769 | 1.00 | PPARG (0.85) | PPARGPPARAFFAR1 | |
| SCHEMBL6939776 | 0.95 | PPARG (0.78) | PPARGPPARA | |
| SCHEMBL8805571 | 0.95 | PPARG (0.78) | PPARGPPARA | |
| SCHEMBL8804308 | 0.93 | PPARG (0.77) | PPARGPPARAFFAR1 | |
| SCHEMBL8804772 | 0.93 | PPARG (0.77) | PPARGPPARAFFAR1 | |
| SCHEMBL6713386 | 0.92 | PPARG (1.00) | PPARGPPARA | |
| SCHEMBL9129979 | 0.89 | PPARA (0.66) | PPARGPPARAFFAR1 | |
| SCHEMBL6940318 | 0.88 | PPARA (0.67) | PPARGPPARAFFAR1 | |
| SCHEMBL8805888 | 0.85 | PPARA (0.80) | PPARGPPARA | |
| SCHEMBL8805008 | 0.85 | PPARA (0.80) | PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0533781-B1 | 3-ARYL-2-HYDROXYPROPIONIC ACID DERIVATIVES AND ANALOGS AS HYPOGLYCEMIC AGENTS | PFIZER (US) | 1997-02-26 | — | — | EP | disclosed |
| US-5438074-A | 3-aryl-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents | PFIZER INC. (US) | 1995-08-01 | — | — | US | disclosed |
| US-5306726-A | 3-aryl-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents | PFIZER INC. (US) | 1994-04-26 | — | — | US | disclosed |
| US-5232945-A | 3-aryl-2-hydroxypropionic acid derivatives and analogs as antihypertensives | PFIZER INC. (US) | 1993-08-03 | — | — | US | disclosed |
| EP-0533781-A1 | 3-ARYL-2-HYDROXYPROPIONIC ACID DERIVATIVES AND ANALOGS AS HYPOGLYCEMIC AGENTS. | PFIZER (US) | 1993-03-31 | — | — | EP | disclosed |
| WO-1991019702-A1 | 3-ARYL-2-HYDROXYPROPIONIC ACID DERIVATIVES AND ANALOGS AS HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1991-12-26 | — | — | WO | disclosed |