Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MITF | O75030 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL990668 | 0.81 | NR4A2 (0.71) | NR4A2HTTALDH1A1SMN1; SMN2POLB | |
| SCHEMBL4685270 | 0.77 | NR4A2 (0.57) | NR4A2HTTALDH1A1SMN1; SMN2POLB | |
| SCHEMBL14828742 | 0.76 | ALDH1A1 (0.63) | NR4A2HTTALDH1A1SMN1; SMN2POLB | |
| SCHEMBL1558956 | 0.76 | POLB (0.68) | NR4A2HTTALDH1A1SMN1; SMN2POLB | |
| SCHEMBL3242026 | 0.75 | ALDH1A1 (0.58) | NR4A2HTTALDH1A1SMN1; SMN2POLB | |
| SCHEMBL8803982 | 0.74 | ALDH1A1 (0.61) | NR4A2HTTALDH1A1SMN1; SMN2POLB | |
| SCHEMBL3721490 | 0.74 | ALDH1A1 (0.61) | NR4A2HTTALDH1A1SMN1; SMN2POLB | |
| SCHEMBL461911 | 0.74 | ALDH1A1 (0.64) | NR4A2HTTALDH1A1SMN1; SMN2POLB | |
| SCHEMBL5328102 | 0.74 | MEN1 (0.58) | HTTALDH1A1KMT2ALMNAMAPT | |
| SCHEMBL1887873 | 0.72 | NR4A2 (0.67) | NR4A2HTTALDH1A1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0540956-B1 | Process for the manufacture of substituted maleimides | HOFFMANN LA ROCHE (CH) | 1997-09-03 | — | — | EP | disclosed |
| US-5399712-A | Protein kinase C inhibitor | HOFFMANN-LA ROCHE INC. (US) | 1995-03-21 | — | — | US | disclosed |
| EP-0540956-A1 | Process for the manufacture of substituted maleimides | F. HOFFMANN-LA ROCHE AG (CH) | 1993-05-12 | — | — | EP | disclosed |