Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.69 |
| ▸ | NPC1 | O15118 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.55 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL880497 | 0.87 | KMT2A (0.53) | MEN1NPC1KMT2ATDP1L3MBTL1 | |
| SCHEMBL880353 | 0.85 | KMT2A (0.63) | MEN1NPC1KMT2ATDP1L3MBTL1 | |
| SCHEMBL880352 | 0.85 | KMT2A (0.73) | MEN1NPC1KMT2ATDP1L3MBTL1 | |
| SCHEMBL880263 | 0.83 | KMT2A (0.60) | MEN1NPC1KMT2ATDP1L3MBTL1 | |
| SCHEMBL30866425 | 0.83 | KMT2A (0.60) | MEN1NPC1KMT2ATDP1L3MBTL1 | |
| SCHEMBL8303883 | 0.82 | DDB1 (0.74) | MEN1NPC1KMT2ATDP1L3MBTL1 | |
| SCHEMBL19217471 | 0.82 | SMN1; SMN2 (0.53) | MEN1NPC1KMT2ATDP1L3MBTL1 | |
| SCHEMBL7156373 | 0.80 | ALDH1A1 (0.58) | MEN1NPC1KMT2ATDP1L3MBTL1 | |
| SCHEMBL880376 | 0.80 | ALDH1A1 (0.58) | MEN1NPC1KMT2ATDP1L3MBTL1 | |
| SCHEMBL12698414 | 0.80 | ALDH1A1 (0.58) | MEN1NPC1KMT2ATDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8440705-B2 | 2,3,4,7,8,9-hexahydro-1H-cyclopenta[h]quinolin-2-one or 2,3,4,6,7,8-hexahydro-1H-cyclopenta[g]quinolin-2-one; Alzheimer's disease | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2013-05-14 | — | — | US | disclosed |
| EP-2433634-A2 | Compounds, compositions and methods of inhibiting a-synuclein toxicity | The Whitehead Institute for Biomedical Research (US) | 2012-03-28 | — | — | EP | disclosed |