Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PEPD | P12955 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | FDPS | P14324 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | PGK1 | P00558 | 1/20 | 0.31 |
| ▸ | PGK2 | P07205 | 1/20 | 0.31 |
| ▸ | PGD | P52209 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL27632827 | 0.94 | PEPD (0.46) | PEPDCA4FFAR3LCKFYN | |
| SCHEMBL49771 | 0.94 | — | — | |
| SCHEMBL16795494 | 0.94 | CA4 (0.50) | PEPDCA4ALDH1A1TSHRFDPS | |
| SCHEMBL10597462 | 0.91 | CA4 (0.48) | PEPDCA4ALDH1A1TSHRFDPS | |
| SCHEMBL6246557 | 0.91 | CA4 (0.48) | PEPDCA4ALDH1A1TSHRFDPS | |
| SCHEMBL1677255 | 0.91 | — | — | |
| Ammonia Solution, Strong SCHEMBL11578534 | 0.91 | — | — | |
| SCHEMBL5313172 | 0.91 | CA4 (0.48) | PEPDCA4ALDH1A1TSHRFDPS | |
| Phosphoric Acid SCHEMBL16447462 | 0.91 | CA4 (0.48) | PEPDCA4ALDH1A1TSHRFDPS | |
| Ammonia Solution, Strong SCHEMBL10598792 | 0.91 | CA4 (0.48) | PEPDCA4ALDH1A1TSHRFDPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106190936-B | Bacterium and construction method and application thereof | 上海交通大学 | 2020-07-10 | — | — | CN | claimed |
| CN-106190901-B | Bacterium and obtaining method and application thereof | 上海交通大学 | 2020-06-26 | — | — | CN | claimed |
| US-20190218629-A1 | Bacterium And Obtaining Method And Application Thereof | SHANGHAI JIAO TONG UNIVERSITY (CN) | 2019-07-18 | — | — | US | claimed |
| CN-106190901-A | A kind of bacterium and acquisition methods thereof and application | 上海交通大学 | 2016-12-07 | — | — | CN | claimed |
| CN-106190936-A | A kind of bacterium and construction method thereof and application | 上海交通大学 | 2016-12-07 | — | — | CN | claimed |
| CN-118995846-A | Enzymatic synthesis of 4' -ethynyl nucleoside analogues | 默沙东有限责任公司 | 2024-11-22 | — | — | CN | disclosed |
| US-20240301460-A1 | ENZYMATIC SYNTHESIS OF 4'-ETHYNYL NUCLEOSIDE ANALOGS | MERCK SHARP & DOHME LLC (US) | 2024-09-12 | — | — | US | disclosed |
| CN-112996511-B | Enzymatic synthesis of 4' -ethynyl nucleoside analogues | 默沙东有限责任公司 | 2024-08-09 | — | — | CN | disclosed |
| US-12037623-B2 | Enzymatic synthesis of 4′-ethynyl nucleoside analogs | Merck, Sharp & Dohme LLC (US) | 2024-07-16 | — | — | US | disclosed |
| US-20240191263-A1 | BACTERIAL AND YEAST COMBINATIONS FOR REDUCING GREENHOUSE GAS PRODUCTION DURING FERMENTATION OF BIOMASS COMPRISING HEXOSES | LALLEMAND HUNGARY LIQUIDITY MANAGEMENT LLC (HU) | 2024-06-13 | — | — | US | disclosed |
| US-20240191262-A1 | BACTERIAL AND YEAST COMBINATIONS FOR REDUCING GREENHOUSE GAS PRODUCTION DURING FERMENTATION OF BIOMASS COMPRISING PENTOSES | DANSTAR FERMENT AG (CH) | 2024-06-13 | — | — | US | disclosed |
| US-11946036-B2 | Bacterium and obtaining method and application thereof | SHANGHAI JIAO TONG UNIVERSITY (CN) | 2024-04-02 | — | — | US | disclosed |
| EP-0422100-A4 | — | — | 1994-04-27 | — | — | EP | disclosed |
| US-5073548-A | Antiprogestational, progestational and antiglucocorticoid activity; glandular disorders; vision defects; antifertility agents | RESEARCH TRIANGLE INSTITUTE (US) | 1991-12-17 | — | — | US | disclosed |
| EP-0422100-A1 | 11-g(b)-SUBSTITUTED PROGESTERONE ANALOGS. | RES TRIANGLE INST (US) | 1991-04-17 | — | — | EP | disclosed |
| US-4954490-A | HORMONE INHIBITORS | RESEARCH TRIANGLE INSTITUTE (US) | 1990-09-04 | — | — | US | disclosed |
| WO-1989012448-A1 | 11beta-SUBSTITUTED PROGESTERONE ANALOGS | RESEARCH TRIANGLE INSTITUTE (US) | 1989-12-28 | — | — | WO | disclosed |
| EP-0181769-A1 | Stimulation of aerobic bacteria | INTERNATIONAL TECHNOLOGY CORPORATION (US) | 1986-05-21 | — | — | EP | disclosed |
| EP-0101721-A1 | STIMULATION OF BACTERIAL GROWTH BY INORGANIC PYROPHOSPHATE | THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 1984-03-07 | — | — | EP | disclosed |
| WO-1983002952-A1 | STIMULATION OF BACTERIAL GROWTH BY INORGANIC PYROPHOSPHATE | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 1983-09-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12037623-B2 | Enzymatic synthesis of 4′-ethynyl nucleoside analogs | GALE, ENGASE, RNGTT | PEPD 71/4885CA4 1767/4885FFAR3 4303/4885 |
| US-20240301460-A1 | ENZYMATIC SYNTHESIS OF 4'-ETHYNYL NUCLEOSIDE ANALOGS | GALE, ENGASE, RNGTT | PEPD 70/4885CA4 1766/4885FFAR3 4310/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.