⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1997009 | 0.71 | CYP3A4 (0.33) | — | |
| SCHEMBL643186 | 0.71 | KDM4E (0.40) | — | |
| SCHEMBL1097061 | 0.70 | — | — | |
| Hydrochloric Acid SCHEMBL4180932 | 0.70 | KDM4E (0.42) | — | |
| SCHEMBL2893466 | 0.68 | AR (0.33) | — | |
| SCHEMBL502805 | 0.67 | KDM4E (0.41) | — | |
| SCHEMBL31577769 | 0.67 | KDM4E (0.41) | — | |
| SCHEMBL31318734 | 0.66 | CASP3 (0.39) | — | |
| SCHEMBL18641400 | 0.66 | CASP3 (0.39) | — | |
| SCHEMBL2178833 | 0.66 | L3MBTL1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0539086-B1 | Condensed pyrimidine derivatives and their use as angiotensine II antagonists | AMERICAN HOME PROD (US) | 1997-12-29 | — | — | EP | disclosed |
| US-5498776-A | Substituted pyrrolopyrimidines and pyridopyrimidines useful as angiotensin II antagonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-03-12 | — | — | US | disclosed |
| US-5451583-A | Angiotensin inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-09-19 | — | — | US | disclosed |
| WO-1994011365-A1 | SUBSTITUTED BENZIMIDAZOLES AND QUINAZOLINES AS ANTIHYPERTENSIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-05-26 | — | — | WO | disclosed |
| US-5283242-A | Hypotensive agents, cardiotonic agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-02-01 | — | — | US | disclosed |
| US-5256654-A | Substituted pyrrolopyrimidines, azepinopyrimidines and pyridopyrimidines useful as angiotensin II antagonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-10-26 | — | — | US | disclosed |
| EP-0539086-A2 | Condensed pyrimidine derivatives and their use as angiotensine II antagonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-04-28 | — | — | EP | disclosed |
| US-5149699-A | Substituted pyridopyrimidines useful as antgiotensin II antagonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-09-22 | — | — | US | disclosed |