Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HRH2 | P25021 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8802881 | 0.84 | SMN1; SMN2 (0.51) | SMN1; SMN2LMNAPOLBALDH1A1HPGD | |
| SCHEMBL8438124 | 0.78 | ESR2 (0.48) | SMN1; SMN2LMNAALDH1A1HPGDKMT2A | |
| SCHEMBL8440018 | 0.76 | MEN1 (0.41) | SMN1; SMN2LMNAPOLBALDH1A1HPGD | |
| SCHEMBL8446357 | 0.75 | SMN1; SMN2 (0.51) | SMN1; SMN2LMNAPOLBALDH1A1HPGD | |
| SCHEMBL21767046 | 0.73 | LMNA (0.43) | SMN1; SMN2LMNAPOLBALDH1A1KMT2A | |
| SCHEMBL11818022 | 0.73 | CHRM2 (0.43) | SMN1; SMN2LMNAPOLBALDH1A1TMEM97 | |
| SCHEMBL30647004 | 0.72 | PRMT5 (0.55) | SMN1; SMN2ALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL15355387 | 0.72 | PRMT5 (0.55) | SMN1; SMN2ALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL1859157 | 0.71 | SMN1; SMN2 (0.69) | SMN1; SMN2LMNAPOLBALDH1A1HPGD | |
| SCHEMBL3634052 | 0.71 | SMN1; SMN2 (0.69) | SMN1; SMN2LMNAPOLBALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0785939-A1 | SUBSTITUTED HETEROBICYCLIC ALKYL AMINES AND THEIR USE AS SQUALENE OXIDE CYCLASE INHIBITORS | Takeda Chemical Industries, Ltd. (JP) | 1997-07-30 | — | — | EP | disclosed |
| WO-1996011201-A1 | SUBSTITUTED HETEROBICYCLIC ALKYL AMINES AND THEIR USE AS SQUALENE OXIDE CYCLASE INHIBITORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-04-18 | — | — | WO | disclosed |