Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.55 |
| ▸ | HTR1A | P08908 | 3/20 | 0.55 |
| ▸ | DRD2 | P14416 | 2/20 | 0.55 |
| ▸ | HTR7 | P34969 | 1/20 | 0.55 |
| ▸ | HTR6 | P50406 | 1/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12845524 | 0.95 | HDAC3 (0.53) | HTR2AHTR1ADRD2HTR7HTR6 | |
| SCHEMBL12782483 | 0.91 | HDAC3 (0.56) | HTR2AHTR1ADRD2HTR7HTR6 | |
| Serdemetan SCHEMBL29375950 | 0.85 | HRH3 (0.58) | HTR2AHTR1ADRD2HTR7HTR6 | |
| Serdemetan SCHEMBL3012498 | 0.85 | HRH3 (0.58) | HTR2AHTR1ADRD2HTR7HTR6 | |
| SCHEMBL12782524 | 0.84 | HDAC3 (0.47) | HTR2AHTR1ADRD2HTR7HTR6 | |
| SCHEMBL12782284 | 0.82 | HRH3 (0.61) | HTR2AHTR1ADRD2HTR7HTR6 | |
| SCHEMBL13130727 | 0.81 | KMT2A (0.46) | HTR2AHTR1ADRD2HTR7HTR6 | |
| SCHEMBL12845346 | 0.81 | HRH3 (0.59) | HTR2AHTR1ADRD2HTR7HTR6 | |
| SCHEMBL12845544 | 0.80 | HRH3 (0.61) | HTR2AHTR1ADRD2HTR7HTR6 | |
| SCHEMBL7004146 | 0.79 | HTR2A (0.71) | HTR2AHTR1AHTR7HTR6KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0775131-A2 | INDOL, INDAZOL, PYRIDOPYRROL AND PYRIDOPYRAZOL DERIVATIVES WITH ANTI-ASTHMATIC, ANTI-ALLERGIC, ANTI-INFLAMMATORY AND IMMUNOMODULATING EFFECTS | ASTA Medica Aktiengesellschaft (DE) | 1997-05-28 | — | — | EP | disclosed |
| WO-1996004266-A2 | INDOL, INDAZOL, PYRIDOPYRROL AND PYRIDOPYRAZOL DERIVATIVES WITH ANTI-ASTHMATIC, ANTI-ALLERGIC, ANTI-INFLAMMATORY AND IMMUNOMODULATING EFFECTS | ASTA MEDICA AKTIENGESELLSCHAFT (DE) | 1996-02-15 | — | — | WO | disclosed |